Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on the Hepatoprotective Effect and Cytochrome P450 Regulation of Scutellaria Radix

황금의 간보호활성 및 Cytochrome P450 발현조절에 관한 연구

  • Ha, Ki-Tae (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Sang-Shin (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim, Cheorl-Ho (Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University) ;
  • Choi, Dall-Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim, June-Ki (Department of Pathology, College of Oriental Medicine, Dongguk University)
  • 하기태 (동국대학교 한의과대학 병리학교실) ;
  • 정상신 (동국대학교 한의과대학 병리학교실) ;
  • 김철호 (성균관대학교 자연과학부 생명과학과) ;
  • 최달영 (동국대학교 한의과대학 병리학교실) ;
  • 김준기 (동국대학교 한의과대학 병리학교실)
  • Published : 2007.12.25
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Abstract

In this study, the liver protective effect of the hot water extracts of Scutellaria radix (SR) was investigated. The SR exhibited a hepatoprotective activity against $CCl_4$-induced liver damage in Sprague-Dawley (SD) rats and Chang cell. And the SR also showed significant decrease of malodialdehyde (MDA) and increase of glutathion (GSH), catalase activity in rat liver homogenate. The expression of cytochrome P450 2E1 (CYP2E1), measured by RT-PCR and western blot, was significantly decreased in the SR treated SD rats and Chang cell. But $CCl_4$ and SR has no significant effect on 1A1 and 3A1 isoform of cytochrome P450. Based on these findings, it is suggested that hepatoprotective effects of SR possibly related to antioxidative effects and downregulation of CYP2E1 expression.

Keywords

References

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