Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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The Effect of Herbal Formula KH-305 on Erectile Dysfunction in Hyperlipidemic Rat

고지혈증 흰쥐에서 발기부전에 대한 생약제제 KH-305의 효과

  • 이은정 ((주)KMSI 부설 한국의과학연구소) ;
  • 김희석 ((주)KMSI 부설 한국의과학연구소) ;
  • 김병철 ((주)KMSI 부설 한국의과학연구소) ;
  • 황성완 ((주)KMSI 부설 한국의과학연구소) ;
  • 황성연 ((주)KMSI 부설 한국의과학연구소)
  • Published : 2007.05.30
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Abstract

This study was designed to investigate effects of KH-305 on erectile dysfunction in hyperlipidemic rat. KH-305 has been evaluated for antihyperlipidemic and antierectile dysfunction effects on experimental hyperlipidemic rats induced by high cholesterol-diet. After oral administration of KH-305 water extract (50, 100, 200, 300 mg/kg) to hyperlipidemic rats for 8 weeks, the variables including body weight, total cholesterol, HDL-, and LDL-cholesterol levels in serum, the expression of eNOS and nNOS in penis were measured. Also, erectile function was determined by the measurements of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve. Oral administration of KH-305 extracts significantly inhibited the increase of serum total cholesterol and LDL-cholesterol levels and the decrease of serum HDL-cholesterol level in hyperlipidemic rats induced by high fat diet. The penile expression level of the two enzymes (eNOS, nNOS) were increased significantly after oral administration of the KH-305 extracts. Erectile function after 10 volts stimulation was significantly decreased in the hyperlipidemic rat compared with the normal rat, but increased in KH-305 group compared with hyperlipidemic group. These results suggest that KH-305 is effective for erectile dysfunction in hyperipidemia.

저자들은 일반 흰쥐를 1.5% cholesterol과 0.25% cholic acid, 우지 25% 첨가한 식이로 고지혈증을 유발시킨 후 KH-305를 8주간 경구투여하여 혈중 cholesterol과 HDL-C, LDL-C 등을 측정, 지질대사에 미치는 영향을 알아보았다. 또한, 최대해면체 내압과 내피 관련 NOS 발현정도를 측정하여 음경발기 촉진 및 지속에 미치는 영향을 알아보았다. 그 결과 KH-305를 투여한 모든 그룹에서 고지방식이 그룹보다 총 cholesterol 수치와 LDL-C를 낮추었으며 HDL-C의 수치를 높였다. 최대해면체 내압에서는 KH-305 투여 그룹이 고지방식이 그룹보다 최대해면체 내압에 이르는 시간이 짧았고 최대해면체 내압의 수치가 높았으며 이 중 300mg/kg일 경우 가장 효과가 좋았다. 또한, KH-305 모든 투여 그룹은 고지방식이 그룹과 비교해 볼 때 모든 그룹에서 eNOS와 nNOS의 발현이 뚜렷이 증가되었다. 따라서, 혈중 cholesterol을 낮추면서 NOS의 발현을 증가, 최대해면체 내압이 큰 KH-305는 고지혈증으로 유발된 발기부전에 효능이 있는 약물이 될 수 있으리라 사료된다.

Keywords

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