Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
권호 표지

Endoplnsmic Reticulum Stress Up-regulates Ferritin Heavy Chain 1 Expression

  • Jin, Cho-Yi (Department of Anatomy, College of Medicine, Chungnam National University) ;
  • Kwon, Ki-Sang (Department of Anatomy, College of Medicine, Chungnam National University) ;
  • Yun, Eun-Young (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, R.D.A.) ;
  • Goo, Tae-Won (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, R.D.A.) ;
  • Kwon, O-Yu (Department of Anatomy, College of Medicine, Chungnam National University)
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  • 권오유 (충남대학교 의과대학 해부학교실)
  • Published : 2007.06.30
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Abstract

Ferritin heavy chain 1 (FTH1) is an ubiquitous and highly conserved protein which plays a major role in iron homeostasis. The expression of FTH1 was specifically enhanced under various condition of endoplasmic reticulum (ER) stresses drugs such as Brefeldin A (BFA), DTT (Dithiothreitol), calcium ionophore A23187 and tunicamycin. We firstly report here that ER-stress induces up-regulated expression of FTH1 in FRTL-5 culture thyrocytes.

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