Korean Journal of Materials Research (한국재료학회지)

Materials Research Society of Korea (한국재료학회)
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Fabrication of Porous β-TCP Bone Graft Substitutes Using PMMA Powder and their Biocompatibility Study

PMMA를 이용한 다공질 β-TCP 골충진제 제조 및 생체적합성 평가

  • Song, Ho-Yeon (Department of Microbiology, School of Medicine, Soonchunhyang University) ;
  • Youn, Min-Ho (Department of Biomedical Engineering & Materials, School of Medicine, Soonchunhyang University) ;
  • Kim, Young-Hee (Department of Microbiology, School of Medicine, Soonchunhyang University) ;
  • Min, Young-Ki (Department of Physiology, School of Medicine, Soonchunhyang University) ;
  • Yang, Hun-Mo (Department of Physiology, School of Medicine, Soonchunhyang University) ;
  • Lee, Byong-Taek (Department of Biomedical Engineering & Materials, School of Medicine, Soonchunhyang University)
  • 송호연 (순천향대학교 의과대학 미생물학교실) ;
  • 윤민호 (순천향대학교 의과대학 의공학교실) ;
  • 김영희 (순천향대학교 의과대학 미생물학교실) ;
  • 민영기 (순천향대학교 의과대학 생리학교실) ;
  • 양훈모 (순천향대학교 의과대학 생리학교실) ;
  • 이병택 (순천향대학교 의과대학 의공학교실)
  • Published : 2007.06.27
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Abstract

Porous ${\beta}-tricalcium$ phosphate $({\beta}-TCP)$ bioceramic was fabricated by pressureless sintering using commercial HAp and different volume percentages of PMMA powders (30-60 vol.%). The range of spherical pore size was about $200-250\;{\mu}m$ in diameter. By increasing the PMMA content, the number of pores and their morphology were dramatically changed as well as decreased the material properties. In case of using 60 vol.% PMMA content, network-type pores were found, due to the necking of the PMMA powders. The values of relative density, elastic modulus, bending strength and hardness of the 60 vol.% PMMA content sample, sintered at $1500^{\circ}C$, were about 46%, 22.2 GPa, 5MPa and 182 Hv respectively. Human osteoblast-like MG-63 cells and osteoclast-like Raw 264.7 cells were well grown and fully covered all of the porous ${\beta}-TCP$ bodies sintered at $1500^{\circ}C$.

Keywords

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