Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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A Topographically Correlational Study of P300 and MMN (mismatch negativity) in Healthy Subjects

P300과 MMN(mismatch negativity)의 지형학적 상관연구

  • Kim, Dae-Sik (Department of Clinical Laboratory Science, Dongnam health college) ;
  • Kim, Young-Bae (Electrophysiology Laboratory, Our Lady of Mercy Hospital, Catholic University)
  • 김대식 (동남보건대학 임상병리과) ;
  • 김영배 (가톨릭대학교 성모자애병원 전기생리학 검사실)
  • Published : 2007.12.31
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Abstract

P300 is widely used as a neurophysiological indicator of cognitive processing, which is known as reflecting controlled processing. MMN (mismatch negativity), early response prior to P300, is known as reflecting an early stage of information processing and having involuntary attention and automatic awakening or sensory memory. This study for normal people shows that electric potential of P300 and MMN are in close correlation (r=-0.673, p<0.05). That is, it is observed that the higher negative value electric potential of MMN measured at cerebral forehead-center has, the higher value electric potential of P300 measured at cerebral center-vertex has. This fact implies that working memory for temporary storage and operation of stimuli, and involuntary attention which constitute automatic information processing, an early stage of information processing, play a crucial role in efficient information processing. On the other hand, considering that MMN of cerebral forehead-center and P300 of cerebral center-vertex are in close correlation, it is necessary to pursue further study of cerebral parts which generate P300 and MMN in information processing.

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