Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지

Effect of Hominis placenta Herbal Acupuncture on Type II Collagen-induced Arthritis in Mice

자하차(紫河車)약침이 제2형 콜라겐 유발 관절염에 미치는 영향

  • Jo, Young-Wook (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
  • Lee, Sung-Woo (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
  • Kang, Min-Joo (Lee Sung Soo Oriental Medical Clinic) ;
  • Kim, Eun-Jung (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
  • Lee, Seung-Deok (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
  • Kim, Kap-Sung (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University)
  • 조영욱 (동국대학교 한의과대학 침구학교실) ;
  • 이승우 (동국대학교 한의과대학 침구학교실) ;
  • 강민주 (이성수한의원) ;
  • 김은정 (동국대학교 한의과대학 침구학교실) ;
  • 이승덕 (동국대학교 한의과대학 침구학교실) ;
  • 김갑성 (동국대학교 한의과대학 침구학교실)
  • Published : 2007.12.20
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : We investigated the effects of Hominis placenta Herbal acupuncture on rheumatoid arthritis. Methods : We investigated the Type II collagen-induced arthritis test, vascular permeability test, phenyl benzoquinone-induced writhing test, hot plate test, carbon clearance test, determination of prostaglandin $E_2$ content and cyclooxygenase-2 activity test. Results : Hominis placenta Herbal acupuncture suppressed Type II collagen-induced arthritis in DBA/1J mice and vascular permeability with 10.2% inhibition in ICR mice. We see the phenyl benzoquinone-induced writhing test and the hot plate test in the analgesic activity test. In the phenyl benzoquinone-induced writhing test, Hominis placenta Herbal acupuncture showed that it increased its analgesic effect more than the control(test?) by 85.5%. In the hot plate test, it was also shown that the analgesic effect increased more than the control(test) by 32.1%. In the carbon clearance test, the immuno-stimulatory effect showed more than the control(test) by 8.0%. The formation of prostaglandin $E_2$ was also reduced more than the control(test) by 10.1%. Finally, cyclooxygenase-2 activity was inhibitedwith 36.3%. Conclusions : Hominis placenta Herbal acupuncture may be useful for the treatment of rheumatoid arthritis after injection.

Keywords