Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Traditional Wine by using Mycelium of Phellinus linteus on the Expression of Inflammation-Related Proteins in Rat Liver

상황버섯 균사체를 이용한 전통주의 장기투여가 흰쥐 간장에 미치는 영향

  • Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University) ;
  • Lee, Yong-Tae (Department of Physiology, College of Oriental Medicine, Dong-Eui University) ;
  • Chung, Kyung-Tae (Department of Biomedical laboratory Science, College of Natural Science, Dong-Eui University) ;
  • Jeong, Young-Kee (Department of Biotechnology, College of Natural Resources and Life Science, Dong-A University) ;
  • Choi, Byung-Tae (Department of Anatomy, College of Oriental Medicine, Dong-Eui University)
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 이용태 (동의대학교 한의과대학 생리학교실) ;
  • 정경태 (동의대학교 자연과학대학 임상병리학과) ;
  • 정영기 (동아대학교 생명자원과학대학 생명공학과) ;
  • 최병태 (동의대학교 한의과대학 해부학교실)
  • Published : 2007.06.25
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Abstract

It was examined that the effect of fermented traditional wine made by using mycelium of Phellinus linteus (TWPL) on the expression of inflammation-related proteins in rat liver. Levels of aspartate aminotransferase (AST) was significantly increased in the serum of ethanol-treated rats compared to normal. However, the level of AST showed no significant changes in the TWPL-treated rat compared normal. Slight histopathological changes of liver such as cloudy swelling, inflammatory cells infiltration, Kupffer cell reaction were demonstrated in the rats challenged with ethanol compared with normal. Fewer scores of these changes were observed in TWPL-treated rat with recovered glycogen in hepatocytes of whole hepatic lobule. The RT-PCR and Western analysis showed that the expression of inflammatory proteins such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor (TNF)-${\alpha}$ were decreased in the TWPL-treated rat compared with ethanol-treated ones. Immunohistochemical analysis showed that the expression of interleukin-lf and TNF-${\alpha}$ tended to decrease in TWPL-treated rat compared with ethanol-treated ones. These results suggest that TWPL may contains some protective agent for alcohol-induced liver injury through a regulating inflammation-related proteins.

Keywords

References

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