YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Hepatoprotective and a Potential Antiviral Effect of Biphenyl Dimethyl Dicarboxylate/Amantadine for an Acute Viral Hepatitis Induced by MHV-2 in ICR Mice

마우스 간염바이러스(MHV-2)에 의해 유발된 전격성 바이러스간염에 대한 비페닐메칠디카르복실레이트/아만타딘제제의 간보호 및 잠재적 항바이러스효과

  • Published : 2007.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial treatment of dimethyl dicarboxylate/amantadine (2:1) showed hepatoprotective and/or antiviral properties in MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2 d)after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p<0.01). Finally, we concluded that those results were probably from the inhibition of viral replication and at least antiproliferative effect on MHV-2.

Keywords

References

  1. Lok, A. S. : Chronic hepatitis B. Engl. J. Med. 346, 1682 (2002) https://doi.org/10.1056/NEJM200201033460102
  2. Park, J. W. : Hepatocellular carcinoma in Korea: introduction and overview. Korean J. Gastroenterol. 45, 217 (2005)
  3. Chisari, F. V., Ferrari, C. and Mondelli, M. U. : Hepatitis B virus structure and biology. Microb. Pathog. 6, 311 (1989)
  4. Kim, S. M., Lee, K. S., Park, C. J., Lee, J. Y., Kim, K. H., Park, J. Y., Lee, J. H., Kim, H. Y., Yoo, J. Y. and Jang, M. K. : Prevalence of occult HBV infection among subjects with normal serum ALT levels in Korea. J. Infection 54, 185 (2007) https://doi.org/10.1016/j.jinf.2006.02.002
  5. Wong, D. K., Cheung, A. M., O'Rourke, K., Naylor, C. D., Detsky, A. S. and Heathcote, J. : Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis. Ann. Intern. Med. 119, 312 (1993)
  6. Liaw, Y. F., Leung, N. M., Chang, T. T., Guan, R., Tai, D. I., Ng, K. Y., Chien, R. N., Dent, J., Roman, L., Edmunson, S. and Lai, C. L. : Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia hepatitis lamivudine study group. Gastroenterology 119, 172 (2000)
  7. Clercq, D. E. : Antiviral drugs in current clinical use. J. Clin. Virol. 30, 115 (2004) https://doi.org/10.1016/j.jcv.2004.02.009
  8. Kang, K. W., Kim, Y. G., Kim, C. W. and Kim, S. G. : The anti-fibrogenic effect of a pharmaceutical composition of [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl- 2,2'-dicarboxylate (DDB). Arch. Pharm. Res. 25, 655 (2002)
  9. Pinto, L. H. and Lamb, R. A. : The M2 proton channels of influenza A and B viruses. J. Biol. Chem. 7, 8997 (2006)
  10. Wang, C., Takeuchi, K., Pinto, L. and Lamb, R. A. : Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. J. Virol. 67, 585 (1993)
  11. Joo, S. S., Won, T. J., Kim, M. J., Hwang, K. W. and Lee, D. I. : Interferon signal transduction of biphenyl dimethyl dicarboxylate/ amantadine and anti-HBV activity in HepG2 2.2.15. Arch. Pharm. Res. 29, 405 (2006) https://doi.org/10.1007/BF02968591
  12. Sun, N. and Perlman, S. : Spread of a neurotropic coronavirus to spinal cord white matter via neurons and astrocytes. J. Virol. 69, 633 (1995)
  13. Abe, S., Ota, Y., Koike, S., Kurata, T., Horie, H., Nomura, T., Hashizume, S. and Nomoto, A. : Neurovirulence test for oral live poliovaccines using poliovirus-sensitive transgenic mice. Virology 206, 1075 (1995)
  14. Seglen, P. O. : Preparation of isolated rat liver cells. Methods Cell Biol. 13, 29 (1976)
  15. Matsuyama, S., Henmi, S., Ichihara, N., Sone, S., Kikuchi, T., Ariga, T. and Taguchi, F. : Protective effects of murine recombinant interferon-${\beta}$ administered by intravenous, intramuscular or subcutaneous route on mouse hepatitis virus infection. Antivir. Res. 47, 131 (2000)
  16. Joo, S. S. and Lee, D. I. : The potential anti-HBV effect of amantadine in combination with ursodeoxycholic acid and biphenyl dimethyl dicarboxylate in HepG2 2.2.15. Arch. Pharm. Res. 28, 451 (2005) https://doi.org/10.1007/BF02977675
  17. Fuchizaki, U., Kaneko, S., Nakamoto, Y., Sugiyama, Y., Imagawa, K., Kikuchi, M. and Kobayashi, K. : Synergistic antiviral effect of a combination of mouse interferon-alpha and interferon-gamma on mouse hepatitis virus. J. Med. Virol. 69, 188 (2003) https://doi.org/10.1002/jmv.10286