Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Changes in Chemical Composition and Biological Activities of Oriental Crude Drugs by Food Processing Techniques IV - Increase in 5-HMF Content of Aurantii nobilis Pericarpium During Roasting Process -

식품학적 가공에 의한 생약의 성분 및 활성 변화 IV - Roasting처리에 의한 진피 중 5-HMF 함량증가 -

  • Ni, Qinxue (School of Applied Life Sciences, College of Agriculture and Life Sciences, Kyungpook National University) ;
  • Hur, Jong-Moon (School of Applied Life Sciences, College of Agriculture and Life Sciences, Kyungpook National University) ;
  • Choi, Sun-Ha (School of Applied Life Sciences, College of Agriculture and Life Sciences, Kyungpook National University) ;
  • Yang, Eun-Ju (School of Applied Life Sciences, College of Agriculture and Life Sciences, Kyungpook National University) ;
  • Lee, Yu-Mi (Department of Genetic Engineering, College of Natural Sciences, Kyungpook National University) ;
  • Kang, Young-Hwa (School of Applied Life Sciences, College of Agriculture and Life Sciences, Kyungpook National University) ;
  • Song, Kyung-Sik (School of Applied Life Sciences, College of Agriculture and Life Sciences, Kyungpook National University)
  • 예근학 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 허종문 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 최선하 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 양은주 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 이유미 (경북대학교 농업생명과학대학 생명공학부) ;
  • 강영화 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 송경식 (경북대학교 농업생명과학대학 응용생물화학부)
  • Published : 2007.06.30
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Abstract

Regarding chemical changes in oriental drugs after food processing such as roasting, fermentation, and extrusion, fifty commonly-used medicinal plants were investigated. As a result, Aurantii nobilis Pericarpium (a tangerine peel from Citrus unshu Markovich) showed remarkably different HPLC profiles after being roasted. An increased peak was isolated by repeated chromatography and identified as 5-hydroxymethyl furfral (5-HMF) by means of instrumental analyses. The 5-HMF content of Aurantii nobilis Pericarpoum reached its maximum level after being roasted for 30 min at 225$^{\circ}C$ (49.2 mg/g extract, ca 42 times of increase over untreated control). Although there were no significant changes in in vitro biological activity such as antioxidative, anti-dementia, anti-hypertension, anti-coagulation, or cytotoxicity, before and after roasting process, our results suggested that simple heat treatment might improve the value of the above oriental drug since 5-HMF has been known to possess inhibitory activities toward nitric oxide formation, tyrosinase, and sickling of red blood cells.

Keywords

References

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