The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Vasodilatory Activities and Safety of the Water Extracts of Three Medicinal Remedy in Species of Insects

활혈효능(活血效能)을 가진 충류약물(蟲類藥物) 3종(種)의 내피세포 의존성 혈관이완작용 및 안전성에 대한 연구

  • Bae, Kyeong-Yeon (Dept. of OB & GY, College of Oriental Medicine, Dongguk University) ;
  • Kim, Eun-Young (Food Chemistry and Biotechnology Division of Korea Food Research Institute) ;
  • Rhyu, Mee-Ra (Food Chemistry and Biotechnology Division of Korea Food Research Institute) ;
  • Roh, Jin-Ju (Dept. of OB & GY, College of Oriental Medicine, Dongguk University) ;
  • Kim, Dong-Il (Dept. of OB & GY, College of Oriental Medicine, Dongguk University)
  • 배경연 (동국대학교 한의과대한 한방부인과학교실) ;
  • 김은영 (한국식품연구개발원 생물공학연구부) ;
  • 류미라 (한국식품연구개발원 생물공학연구부) ;
  • 노진주 (동국대학교 한의과대한 한방부인과학교실) ;
  • 김동일 (동국대학교 한의과대한 한방부인과학교실)
  • Published : 2007.02.28
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Abstract

Purpose : The pharmacological effects of medicinal remedies traditionally used in Asian countries for improving the blood circulation were examined on isolated rat thoracic aorta strips in organ baths. Methods and results : Each experimental medicine was consecutively extracted under reflux with water. Of three medicinal remedies . Hirudo(HI) having the strongest acute relaxant activity in endothelium-intact arteries, Tabanus(TA), Empoly ohaga(EO) were showing dose-dependent relaxant activity. Long-term relaxant effects were showed in Hirudo(HI) and Empoly ohaga(EO). In endothelium-injury test using carbachol, Hirudo(HI), Tabanus(TA) and Empoly of ohaga(EO) were not damaged to endothelium. Conclusion: As a result of this study, the possibility that a part of medicinal remedy may contribute to the beneficial effects in blood circulation was proposed, but inter-individual variation has been observed. Also, further studies on the vasorelaxant effects of these remedies are still required.

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