Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Controlled Release of Nifedipine in Multi-layered Granule System

다중층 과립 시스템에서 니페디핀의 방출 제어

  • Lee, Soo-Young (Fusion Bio Research Center, Korea Research Institute of Chemical Technology) ;
  • Youn, Ju-Yong (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Kim, Byung-Soo (Fusion Bio Research Center, Korea Research Institute of Chemical Technology) ;
  • Kim, Moon-Suk (Fusion Bio Research Center, Korea Research Institute of Chemical Technology) ;
  • Lee, Bong (Department of Polymer Engineering, Pukyong National University) ;
  • Khang, Gil-Son (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Lee, Hai-Bang (Fusion Bio Research Center, Korea Research Institute of Chemical Technology)
  • 이수영 (한국화학연구원 융합바이오기술연구센터) ;
  • 윤주용 (전북대학교 고분자나노공학과) ;
  • 김병수 (한국화학연구원 융합바이오기술연구센터) ;
  • 김문석 (한국화학연구원 융합바이오기술연구센터) ;
  • 이봉 (부경대학교 고분자공학과) ;
  • 강길선 (전북대학교 고분자나노공학과) ;
  • 이해방 (한국화학연구원 융합바이오기술연구센터)
  • Published : 2007.08.21
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Abstract

Multi-layered granules were prepared by a fluidized-bed coater and uniformed granules were obtained with a size range between $950{\sim}1000{\mu}m$ in diameter. The granule system was composed of three layers, i.e. seed layer with sugar sphere bead and a water-swellable polymer, middle layer with a drug, solubilizer and polymer, and the top layer of porous membrane with a polymeric binder. The aim of this work is to find out the dependence of a drug dissolution rate on the amount of a water-soluble binder and a solubilizer in the granule system. The results showed that the higher amount of hydrophilic binder in the porous membrane, gave the bigger pore size and porosity and made faster dissolution rate and also the higher amount of solubilizer in drug layer enhanced the dissolution rate of drug.

Keywords

References

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