Suppressive Effects of Potato (Solanum tuberlosum) on Type II Collagen-Induced Arthritis in DBA/1J Mice

  • Choi, Eun-Mi (Department of Food and Nutrition, Kyung Hee University)
  • Published : 2007.02.28

Abstract

Collagen-induced arthritis (CIA) is a model for some types of human autoimmune rheumatoid arthritis (RA). In this study, we examined whether ethanol extract of potato (Solanum tuberosum) is efficacious against CIA in mice. Potato extracts (100 and 200 mg/kg) were orally administered to DBA/1J mice once daily for 49 day after initial immunization with type II collagen. Clinical assessment of disease and measurement of paw edema were conducted throughout the study. The production of CIA-related rheumatoid factor, anti-type II collagen antibody, and cytokines were examined in DBA/1J mice. Serum levels of AST, ALT, creatinine, and lipids were measured, and antioxidant enzyme activity in the spleen was also determined. The arthritis score and paw edema were markedly suppressed in the groups treated with potato extract. Levels of rheumatoid factor, anti-type II collagen antibody, interleukin (IL)-1, IL-6, LDL-cholesterol, and malondialdehyde in sera were also reduced by potato extract treatment. The activities of glutathione peroxidase and glutathione reductase were increased in the spleens of CIA mice treated with potato extract. These findings suggest that potato extract has suppressive effects on type II collagen-induced arthritis, an animal model for human RA.

References

  1. Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14: 397-440 (1996) https://doi.org/10.1146/annurev.immunol.14.1.397
  2. Arend WP. Physiology of cytokine pathways in rheumatoid arthritis. Arthritis Rheum. 45: 101-106 (2001) https://doi.org/10.1002/1529-0131(200102)45:1<101::AID-ANR90>3.0.CO;2-7
  3. Choi EM. Effects of ethanol extract of Ligularia fischeri leaves on Freund's complete adjuvant-induced model of chronic arthritis in mice. Food Sci. Biotechnol. 15: 277-282 (2006)
  4. Hassan MQ, Hadi RA, Al-Rawi ZS, Padron VA, Stohs SJ. The glutathione defense system in the pathogenesis of rheumatoid arthritis. J. Appl. Toxicol. 21: 69-73 (2001) https://doi.org/10.1002/jat.736
  5. Aeseth J, Haugen M, Forre O. Rheumatoid arthritis and metal compounds - Perspectives on the role of oxygen radical detoxification. Analyst 123: 3-6 (1998) https://doi.org/10.1039/a704840h
  6. Kalavacherla US, Ishaq M, Rao URK, Sachindranath A, Hepsiba T. Malondialdehyde as a sensitive marker of inflammation in patients with rheumatoid arthritis. J. Assoc. Physicians India 42: 775-776 (1994)
  7. Czernichow S, Hercberg S. Interventional studies concerning the role of antioxidant vitamins in cardiovascular diseases: a review. J. Nutr. Health Aging 5: 188-195 (2001)
  8. Wooley PH, Dutcher J, Widmer MB, Gillis S. Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice. J. Immunol. 151: 6602-6607 (1993)
  9. Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature 283: 666-668 (1980) https://doi.org/10.1038/283666a0
  10. Takagishi K, Yamamoto M, Maeda K, Nishimura A, Yonemoto K, Hotokebuchi T, Kaibara N. Effect of deoxyspergualin on collagen arthritis in mice. Clin. Immunol. Immunop. 56: 81-87 (1990) https://doi.org/10.1016/0090-1229(90)90171-L
  11. Singh G. Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. The Am. J. Med. 105: 31S-38S (1998) https://doi.org/10.1016/S0002-9343(98)00072-2
  12. Friedman M, McDonald GM. Potato glycoalkaloids: chemistry, analysis, safety, and plant physiology. Crit. Rev. Plant Sci. 16: 55132 (1997)
  13. Friedman M, Fitch TE, Levin CE, Yokoyama WH. Feeding tomatoes to hamsters reduces their plasma low-density lipoprotein cholesterol and triglycerides. J. Food Sci. 65: 897-900 (2000) https://doi.org/10.1111/j.1365-2621.2000.tb13608.x
  14. Gubarev MI, Enioutina EY, Taylor JL, Visic DM, Daynes RA. Plant derived glycoalkaloids protect mice against lethal infection by Salmonella typhimurium. Phytother. Res. 12: 79-88 (1998) https://doi.org/10.1002/(SICI)1099-1573(199803)12:2<79::AID-PTR192>3.0.CO;2-N
  15. Cham BE. Solasodine glycosides as anticancer agents: pre-clinical and clinical studies. Asia Pac. J. Pharmacol. 9: 113-118 (1994)
  16. McGehee DS, Krasowski MD, Fung DL, Wilson B, Gronert GA, Moss JM. Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism. Anesthesiology 93: 510-519 (2000) https://doi.org/10.1097/00000542-200008000-00031
  17. Heal KG, Sheikh NA, Hollingdale MR, Morrow WJ, Taylor-Robinson MW. Potentiation by a novel alkaloid glycoside adjuvant of a protective cytotoxic cell immune response specific for preerythrocytic malaria candidate antigen. Vaccine 19: 4153-4161 (2001) https://doi.org/10.1016/S0264-410X(01)00166-9
  18. Friedman M, Henika PR, Mackey BE. Effect of feeding solanidine, solasodine, and tomatidine to non-pregnant and pregnant mice. Food Chem. Toxicol. 41: 61-71 (2003) https://doi.org/10.1016/S0278-6915(02)00205-3
  19. Choi EM, Koo SJ. Anti-nociceptive and anti-inflammatory effects of the ethanolic extract of potato (Solanum tuberlosum). Food Agric. Immunol. 16: 29-39 (2005) https://doi.org/10.1080/09540100500064320
  20. Choi EM, Lee KH, Koo SJ. Effects of ethanol wxtract of potato (Solanum tuberlosum) on Freund's complete adjuvant-induced model of chronic arthritis in mice. Food Sci. Biotechnol. 14: 228-232 (2005)
  21. Guide for the Care and Use of Laboratory Animals. Grossblatt N (ed). Institute of Laboratory Animal Resources, National Academy Press, Washington, DC, USA (1996)
  22. Hong H, Johnson P. Antioxidant enzyme activities and lipid peroxidation levels in exercised and hypertensive rat tissues. Int. J. Biochem. Cell B 27: 923-931 (1995) https://doi.org/10.1016/1357-2725(95)00057-V
  23. Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. P. Natl. Acad. Sci. USA 89: 9784-9788 (1992)
  24. Placer ZA, Cushmann LL, Johnson BC. Estimation of products of lipid peroxidation (as malondialdehyde) in biochemical systems. Anal. Biochem. 16: 359-364 (1966) https://doi.org/10.1016/0003-2697(66)90167-9
  25. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47: 469-474 (1974) https://doi.org/10.1111/j.1432-1033.1974.tb03714.x
  26. Flohe L, Gunzler WA. Glutathione peroxidase. Method Enzymol. 105: 115-121 (1984)
  27. Carlberg I, Mannervik B. Glutathione reductase. Method Enzymol. 113: 484-499 (1985) https://doi.org/10.1016/S0076-6879(85)13062-4
  28. Luross JA, Williams NA. The genetic and immunopathological processes underlying collagen-induced arthritis. Immunology 103: 407-416 (2001) https://doi.org/10.1046/j.1365-2567.2001.01267.x
  29. Whitehouse MW, Orr KT, Beck FWJ, Pearson CM. Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition. Immunology 27: 311-315 (1974)
  30. Latha RM, Geetha T, Varalakshmi P. Effect of Vernonia cinerea less flower extract in adjuvant-induced arthritis. Gen. Pharmacol. 31: 601-606 (1998) https://doi.org/10.1016/S0306-3623(98)00049-4
  31. Wang Y, Fang Y, Huang W, Zhou X, Wang M, Zhong B, Peng D. Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats. J. Ethnopharmacol. 98: 37-43 (2005) https://doi.org/10.1016/j.jep.2004.12.022
  32. Whitehouse MW, Beck FJ. Impaired drug metabolism in rats with adjuvant-induced arthritis: a brief review. Drug Metab. Dispos. J.: 251-255 (1973)
  33. Hung DY, Siebert GA, Chang P, Whitehouse MW, Fletcher L, Crawford DHG, Roberts MS. Hepatic pharmacokinetics of propranolol in rats with adjuvant-induced systemic inflammation Am. J. Physiol.-Gastr. L. 290: G343-G351 (2006)
  34. Mahajan A, Sharma R, Khajuria R, Bardi GH, Kapoor B, Gupta V. Rheumatoid arthritis: new developments in biologic therapy. J. Indian Med. Assoc. 104: 327-330 (2006)
  35. Tighe H, Chen PP, Tucker R, Kipps TJ, Roudier J, Jirik FR, Carson DA. Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. J. Exp. Med. 177: 109-118 (1993) https://doi.org/10.1084/jem.177.1.109
  36. Cannella AC, O'Dell JR. Early rheumatoid arthritis: pitfalls in diagnosis and review of recent clinical trials. Drugs 66: 1319-1337 (2006) https://doi.org/10.2165/00003495-200666100-00002
  37. Chu CQ, Field M, Allard S, Abney E, Feldmann M, Maini RN. Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair. Brit. J. Rheumatol. 31: 653-661 (1992) https://doi.org/10.1093/rheumatology/31.10.653
  38. Arend WP, Dayer JM. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor ex in rheumatoid arthritis. Arthritis Rheum. 38: 151-160 (1995) https://doi.org/10.1002/art.1780380202
  39. Marinova-Mutafchieva L, Williams RO, Mason LJ, Mauri C, Feldmann M, Maini RN. Dynamics of pro inflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA). Clin. Exp. Immunol. 107: 507-512 (1997) https://doi.org/10.1046/j.1365-2249.1997.2901181.x
  40. Biemond A, Swaak AJG, Koster JF. Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid. Arthritis Rheum. 27: 760-765 (1984) https://doi.org/10.1002/art.1780270706
  41. Ozgu nes H, Gurer H, Tuncer S. Correlation between plasma malondialdehyde and ceruloplasmin activity values in rheumatoid arthritis. Clin. Biochem. 28: 193-194 (1995) https://doi.org/10.1016/0009-9120(94)00081-6
  42. Gambhir JK, Lali P, Jain AK. Correlation between blood antioxidant levels and lipid peroxidation in rheumatoid arthritis. Clin. Biochem. 30: 351-355 (1997) https://doi.org/10.1016/S0009-9120(96)00007-0
  43. Knekt P, Heliovaara M, Aho K, Alfthan G, Marniemi J, Aromaa A. Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. Epidemiology 11: 402-405 (2000) https://doi.org/10.1097/00001648-200007000-00007