Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Inhibitory Effect of Scutellaria baicalensis Root Extract on Chemical Mediator Release and Immune Response

  • Choi, Se-Young (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Choi, Dong-Kug (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Park, Pyo-Jam (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Choi, Wahn-Soo (College of Medicine, Konkuk University) ;
  • Kim, Jong-Dai (School of Bioscience & Biotechnology, Kangwon National University) ;
  • Shin, Heung-Mook (Department of Physiology, College of Oriental Medicine, Dongguk University) ;
  • Lim, Beong-Ou (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
  • Published : 2007.04.30
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Abstract

Inhibitory effect of Scutellaria baicalensis ethanol extracts (SR) on chemical mediator release and immunoglobulin (Ig) production from Sprague-Dawley rats originated cells as type I allergic reaction was examined. SR showed concentration-dependent inhibition on basal and concanavalin A (ConA)-stimulated Ig production. In the mesenteric lymph node lymphocytes, the inhibitory effect of SR on the IgE production in the presence of Con A was stronger than these on IgA and IgG production. Moreover, tumor necrosis factor-alpha $(TNF-{\alpha})$ production-inhibiting effect of SR in the presence ConA was observed. However, SR did not affect the production of $interferon-{\gamma}$. SR also inhibited histamine release from the peritoneal exudate cells stimulated with a calcium ionophore A23187. In the case of leukotriene B4, SR markedly inhibited it at the concentration of 100 mg/ml. From these results, ethanol extracts obtained from Scutellaria baicalensis may have an anti-allergic effect on the intestinal system of rats.

Keywords

References

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