Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Effects of Methanolic Extract from Salvia miltiorrhiza Bunge on in vitro Antithrombotic and Antioxidative Activities

단삼 메탄올 추출물의 항혈전 및 항산화 효과

  • Yang, Seun-Ah (The Center for Traditional Microorganism Resources (TMR), Keimyung University) ;
  • Im, Nam-Kyung (Department of Food Science and Technology, Keimyung University) ;
  • Lee, In-Seon (The Center for Traditional Microorganism Resources (TMR), Keimyung University)
  • 양선아 (계명대학교 전통미생물자원개발 및 산업화연구(TMR) 센터) ;
  • 임남경 (계명대학교 식품가공학) ;
  • 이인선 (계명대학교 전통미생물자원개발 및 산업화연구(TMR) 센터)
  • Published : 2007.02.28
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Abstract

Salvia miltiorrhiza Bunge is known to potentially prevent arteriosclerosis and hypertension, but its effects on platelet function are not clear. In this study, we evaluated the in vitro antithrombotic activities of the edible plant extract. Methanol extract of S. miltiorrhiza Bunge exhibited about 70% fibrinolytic activity compared to the plasmin control, and inhibited ADP- and collagen-induced platelet aggregation in a concentration-dependent manner with $IC_{50}$ values of 0.42 and 0.07 mg/mL, respectively. S. miltiorrhiza Bunge extract significantly prolonged the activated partial thromboplastin time (APTT) and prothrombin time (PT) compared with control. Moreover, 0.05 mg/mL S. miltiorrhiza Bunge extract contained 87.3% l,l-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity. In conclusion, S. miltiorrhiza Bunge seemed to enhance antithrombotic activity due to its radical scavenging activity. Based on these data, further examination is required to determine the mechanism of platelet-dependent antithrombosis and the effect of polyphenols on platelet function.

단삼 메탄올 추출물의 항혈전 및 항산화 효과를 확인하기 위하여 혈소판의 응고 억제효과, 혈장응고시간의 연장, 혈전용해 활성으로 항혈전 효과를 고찰하였으며 DPPH radical 소거능을 측정하여 항산화 효과를 검토하였다. 그 결과, 단삼의 메탄올 추출물은 항혈전과 항산화에 효과가 있는 것으로 나타났다. 이 추출물은 혈소판응고 억제, 혈액응고시간 연장 및 혈전용해 활성에 모두 효과가 좋은 것으로 나타났으며, 폴리페놀 함량이 높고 DPPH radical 소거능도 매우 좋았다. 이로서 단삼의 높은 DPPH radical 소거능이 항혈전 효과에 영향을 미치는 것으로 사료되며, 정확한 효과 및 혈소판의 기능을 조절하는 기전에 대한 연구는 이 결과들을 바탕으로 현재 진행 중에 있다.

Keywords

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