The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Anti-proliferative Effect of Ulmi Pumilae Cortex Extracts on MCF-7 cells

유근피(楡根皮) 추출물의 유방암 세포주 MCF-7 생장 억제 효과

  • Cho, Seong-Hui (Dept. of Oriental obsterics and Gynecology, Collegy of oriental Medicine, Dong-shin Univ.) ;
  • Cho, Su-In (Dept. of Herbology, Collegy of oriental Medicine, Dong-shin Univ.) ;
  • Na, Won-Min (Dept. of Oriental obsterics and Gynecology, Collegy of oriental Medicine, Dong-shin Univ.) ;
  • Yang, Seung-Jeong (Dept. of Oriental obsterics and Gynecology, Collegy of oriental Medicine, Dong-shin Univ.)
  • 조성희 (동신대학교 한의과대학 부인과학교실) ;
  • 조수인 (동신대학교 한의과대학 본초학교실) ;
  • 나원민 (동신대학교 한의과대학 부인과학교실) ;
  • 양승정 (동신대학교 한의과대학 부인과학교실)
  • Published : 2007.08.29
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Abstract

Purpose: This study was conducted to investigate the anti-proliferative effects of Ulmi Pumilae Cortex Extracts(UPCE) on MCF-7(human, breast, adenocaecinoma) and NIH3T3 (human, murine, fibroblast). Methods: MCF-7 cells and NIH3T3 cells were cultured and seeded in cell culture plates, respectively. UPC was extracted with hot water and then further fractionated it into five types: hexane, chloroform, ethyl acetate, butanol, and water soluable fractions. These five different fractions from UPCE were tested for their anti-proliferative effects on MCF-7 cells and NIH3T3 cells by MMT assay. Results: Among the five solvent-fractions of UPCE, n-hexane fraction and ethyl acetate fraction showed a strong anti-proliferative effects on MCF-7 cells but they displayed significant cytotoxicity on NIH3T3 cells, too. On the other hand, chloroform fraction showed a marked anti-proliferative effects on MCF-7 cells and low cytotoxicity on NIH3T3 cells. Conclusion: Chloloform fraction from UPCE showed selective anti-cancer activities on human breast cancer cell MCF-7 relatively to the other fractions.

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