Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Immuno-regulatory and Anti-cancer Effect of Acorus gramineus Solander

석창포(石菖蒲)의 면역조절 및 항암효과

  • Kim, Nam-Seok (Department of Food Biotechnology, Woosuk University, Jeonju Biomaterials Institute) ;
  • Lee, Kyu-Hee (Department of Food Biotechnology, Woosuk University) ;
  • Kim, Tae-Ho (Department of Food Biotechnology, Woosuk University) ;
  • Bae, Jin-Bum (Department of Food Biotechnology, Woosuk University) ;
  • Kim, Sun-Geun (Department of Food Biotechnology, Woosuk University) ;
  • Jeon, Hoon (College of Pharmacology, Woosuk University) ;
  • Lim, Jong-Phil (College of Pharmacology, Woosuk University) ;
  • Shin, Tae-Yong (College of Pharmacology, Woosuk University) ;
  • Lee, Chang-Hyun (Department of Anatomy, College of Oriental medicine, Woosuk University) ;
  • Jeong, Seung-Il (Jeonju Biomaterials Institute) ;
  • Kwon, Jin (Department of Prosthetics and Orthotics, Korea National College of Rehabilitation and Welfare) ;
  • Oh, Chan-Ho (Department of Food Biotechnology, Woosuk University)
  • 김남석 (우석대학교 식품생명공학과, 전주생물소재연구소) ;
  • 이규희 (우석대학교 식품생명공학과) ;
  • 김태호 (우석대학교 식품생명공학과) ;
  • 배진범 (우석대학교 식품생명공학과) ;
  • 김순근 (우석대학교 식품생명공학과) ;
  • 전훈 (우석대학교 약학대학) ;
  • 임종필 (우석대학교 약학대학) ;
  • 신태용 (우석대학교 약학대학) ;
  • 이창현 (우석대학교 한의과대학 해부학교실) ;
  • 정승일 (전주생물소재연구소) ;
  • 권진 (한국재활복지대학 의료보장구과) ;
  • 오찬호 (우석대학교 식품생명공학과)
  • Published : 2007.08.25
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Abstract

Methanol extracts of Acorus gramineus Solander(AGS) were found to exhibit immuno-regulatory action in BALB/c mice. Oral administration of AGS increased murine splenic T lymphocytes, especially $T_H$ and $T_C/T_S$ subpopulations were increased significantly. Treatment of AGS exerted strong cytotoxicity against U937 and HL60 human leukemia cells. Also, AGS induced apoptosis of U937 leukemia cells in a dose dependent manner. Nitric oxide(NO) production and iNOS gene expression were also increased in AGS-treated RAW264.7 cells. Treatment of AGS increased the expression of p53 gene and decreased the expression of PCNA protein in cultured U937 cells. These data suggest that AGS are effective on the immuno-regulatory action and anti-cancer properties.

Keywords

References

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