대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

삼일신기환(三一腎氣丸)이 methotrexate로 유발(誘發)된 흰쥐의 면역기능저하(免疫機能低下)에 미치는 영향(影響)

The Effect of Samilshinkihwan on Immunosuppression Induced in Rats by Methotrexate

  • 최영아 (대구한의대학교 한의과대학 내과학교실) ;
  • 권은희 (대구한의대학교 한의과대학 내과학교실) ;
  • 이연경 (대구한의대학교 한의과대학 내과학교실) ;
  • 신현철 (대구한의대학교 한의과대학 내과학교실) ;
  • 강석봉 (대구한의대학교 한의과대학 내과학교실) ;
  • 박송기 (대구한의대학교 한의과대학 내과학교실)
  • Choi, Young-Ah (Department of Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Kwon, Eun-Hee (Department of Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Lee, Yeon-Kyeong (Department of Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Shin, Hyeon-Cheol (Department of Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Kang, Seok-Bong (Department of Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Park, Song-Kee (Department of Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University)
  • 발행 : 2007.03.31
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초록

Objective : To investigate the effect of Samilshinkihwan(SISKW) on white rats with deteriorated immunity caused by methotrexate. Methods : The test articles were dosed once a day for 14 days by gastric gavage at a dosage 1000, 500 and 250mg/kg/10ml of SISKW from 2 days after last MTX-dosing, and changes in body weight, spleen weight, total blood leukocyte numbers, total lymphocyte numbers, B and T lymphocyte ratio, CD3+CD4+, CD3+/CD8+ and CD4+/CD8+ T lymphocyte ratio in the blood and spleen were measured. In addition, the serum interleukin (IL)-2 levels and the productivity of IL-2 of splenic cells were also demonstrated in this study. Results : The changes on body weight increased significantly in the 1000mg/kgof SISKW group. The changes on the spleen weight, the total blood leukocytenumbers, the total lymphocyte numbers in the blood and spleen, the ratio of T-cell in the blood and spleen and the ratio of CD3+CD4+ T-cell in spleen increased significantly in all SISKW groups as compared with the control group. The ratio of CD4+/CD8+ T-cells in blood increased significantly. The serum IL-2 levels and productivity of IL-2 of splenic cells increased significantly in 1000 and 500mg/kg SISKW groups as compared with the control group. Conclusions : Samilshinkihwanhas an effect of increasing immune responses, especially on cellular immune responses, in white rats with deteriorated immunity caused by methotrexate.

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