The Growth Inhibition Effect of L-1210 and S-180 Cancer Cell Lines by the Extract from Anemarrhena Asphodeloides

지모(知母) 추출물이 L-1210 및 S-180 암세포주 성장 억제에 미치는 영향

  • Yim, Chi-Hye (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dong-Shin Univ.) ;
  • Cho, Jae-Seung (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dong-Shin Univ.) ;
  • Kim, Hyo-Soo (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dong-Shin Univ.) ;
  • Kwon, Seung-Man (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dong-Shin Univ.) ;
  • Kim, Shin (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dong-Shin Univ.) ;
  • Kim, Il-Hwan (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dong-Shin Univ.) ;
  • Park, Hye-Sun (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dong-Shin Univ.)
  • 임치혜 (동신대학교 한의과대학 사상체질과) ;
  • 초재승 (동신대학교 한의과대학 사상체질과) ;
  • 김효수 (동신대학교 한의과대학 사상체질과) ;
  • 권승만 (동신대학교 한의과대학 사상체질과) ;
  • 김신 (동신대학교 한의과대학 사상체질과) ;
  • 김일환 (동신대학교 한의과대학 사상체질과) ;
  • 박혜선 (동신대학교 한의과대학 사상체질과)
  • Published : 2007.08.31

Abstract

1. Objective This study was aimed to screen the potential antitumor activity of one kinds of Korean medicinal herb extracts against cancer cell lines and to evaluate the growth inhibition effect of L-1210 and S-180 cancer cell lines. 2. Methods It confirmed Anemarrhena asphodeloides extracts to screen the potential antitumor activity. Then, it was extracted with 4 kinds of solvents ; hexane, ethyl acetate, butanol and $H_2O$, and the Growth inhibition effect of these extracts were determined against cancer cell and normal cell. The results were as follows : The IC50(50% inhibitory concentration) values of Anemarrhena asphodeloides extracts were shown to be $253{\mu}g/ml$ against L-1210 cell lines. The IC50 values of ethyl acetate extracts were shown to be $915{\mu}g/ml$ against L-1210 cell lines. The IC50 values of butanol extracts were shown to be $52.3{\mu}g/ml$, $485{\mu}g/ml$ against L-1210, S-180 cell lines, respectively. The butanol extracts were more selectively effective than other extracts to cancer cell lines. 3. Conclusion From these data, it could be concluded that the Anemarrhena asphodeloides extracts to the Growth inhibition effect of L-1210 and S-180 cancer cell lines.

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