Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effects of herbal-aupuncture solution from vitis labrusca root on LPO, RNS and cytochrome P450

포도근 약침액이 LPO, RNS 및 Cytochrome P450에 미치는 효과

  • Lim, Seong-Cheorl (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongguk University) ;
  • Kim, Hyuck (Dept. of Cardiovascular Medical Research Center, College of Oriental Medicine, Dongguk University) ;
  • Lee, Hyo-Seung (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongguk University, Dept. of Cardiovascular Medical Research Center, College of Oriental Medicine, Dongguk University) ;
  • Park, Won-Hwan (Dept. of Diagnostics, College of Oriental Medicine, Dongguk University, Dept. of Cardiovascular Medical Research Center, College of Oriental Medicine, Dongguk University) ;
  • Moon, Jin-Young (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongguk University, Dept. of Cardiovascular Medical Research Center, College of Oriental Medicine, Dongguk University)
  • 임성철 (동국대학교 한의과대학 경혈학교실) ;
  • 김혁 (동국대학교 한의과대학 심혈관계질환 천연물개발연구센터) ;
  • 이효승 (동국대학교 한의과대학 경혈학교실, 동국대학교 한의과대학 심혈관계질환 천연물개발연구센터) ;
  • 박원환 (동국대학교 한의과대학 진단학교실, 동국대학교 한의과대학 심혈관계질환 천연물개발연구센터) ;
  • 문진영 (동국대학교 한의과대학 경혈학교실, 동국대학교 한의과대학 심혈관계질환 천연물개발연구센터)
  • Published : 2007.03.27
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Abstract

Objectives : In this study, we determinated protective effects of Vitis labrusca Root herbal-acupuncture solution (VLHA) against atherosclerosis and cardiovascular disease induced by oxidative damage and cytochrome P450 (CYP) induction. Methods : Antioxidant capacity of VLHA were evaluated by the ${\beta}-carotene/linoleic$ acid emulsion system and FeCl2-ascorbic acid stimulted lipid peroxidation in rat liver homogenate, respectively. Scavenging effects of VLHA on ONOO- and NO were measured by DHR 123, DAF-2 assay. Furthermore, we measured inhibitory activity of VLHA on CYP 2E1 in rat liver microsome using by Aniline assay. Results : VLHA exhibited potent inhibition rate(74%) on FeCl2-ascorbic acid induced lipid peroxidation, and revealed a strong scavenging effects on ONOO- and NO. In addition, VLHA showed inhibitory effect on CYP 2E1. Conclusions : The present study concludes that our results suggest that VLHA could be used as a good source in the prevention of atherosclerosis and alcoholic liver injury.

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