Journal of Embryo Transfer (한국수정란이식학회지)

The Korean Society of Embryo Transfer (한국수정란이식학회)
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Effects of SNPs in Haptoglobin on Average Daily Gain in Pig

Haptoglobin SNP의 돼지 일당 증체량에 관한 효과

  • Kim, Myung-Jick (Animal Biotechnology Division, National Institute of Animal Science, RDA) ;
  • Chung, Ho-Young (Animal Genomics and Bioinformatics Division, National Institutes of Animal Science, RDA) ;
  • Cho, Kyu-Ho (Swine Science Division, National Institutes of Animal Science, RDA) ;
  • Jeon, Gi-Jun (Swine Science Division, National Institutes of Animal Science, RDA) ;
  • Kim, Jin-Hyung (Animal Products Processing Division, National Institutes of Animal Science, RDA)
  • 김명직 (농촌진흥청 축산과학원 응용생명공학과) ;
  • 정호영 (농촌진흥청 축산과학원 동물유전체과) ;
  • 조규호 (농촌진흥청 축산과학원 양돈과) ;
  • 전기준 (농촌진흥청 축산과학원 양돈과) ;
  • 김진형 (농촌진흥청 축산과학원 축산물이용과)
  • Published : 2008.09.30
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Abstract

In order to provide information of genetic variants for Haptoglobin (Hp) gene, which may be related to weight traits in pig, a total of 235 animals from National Institute of Animal Science (NIAS) were screened with 3 primers. The primer sequences were selected using the porcine cDNA sequences based on NM_214000, and the exon boundaries were estimated. Genetic variants were observed using direct sequencing analysis, and there were 9 SNPs detected at nucleotide positions 503 (A/G), 509 (A/G), 709 (C/T), 734 (C/A), 742 (G/A), 769 (A/G), 840 (C/T), 876 (C/T) and 882 (C/A). All the SNPs were located in coding regions, and mutations caused amino acid changes at nucleotide positions 503, 509, 734, 742 and 769. Allele frequencies of SNPs were estimated for all segments. The SNPs at nucleotide position 509 (p<0.0001) and 734 (p<0.05) were significantly associated with average daily gain, but no significance was observed with other SNPs. From the results, the identified SNPs may be a useful candidate marker for the porcine weight gain traits.

Keywords

References

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