Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Therapeutic Effect of Oyaksungisan in Dogs with Facial Nerve Paralysis

개 안면신경마비에 대한 오약순기산의 치료효과

  • Eom, Chang-Sub (College of Veterinary Medicine, Chungnam National University) ;
  • Jun, Hyung-Kyou (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Sang-Hun (College of Veterinary Medicine, Chungnam National University) ;
  • Yun, Hyo-In (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Myung-Cheol (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Duck-Hwan (College of Veterinary Medicine, Chungnam National University)
  • 엄창섭 (충남대학교 수의과대학) ;
  • 전형규 (충남대학교 수의과대학) ;
  • 김상훈 (충남대학교 수의과대학) ;
  • 윤효인 (충남대학교 수의과대학) ;
  • 김명철 (충남대학교 수의과대학) ;
  • 김덕환 (충남대학교 수의과대학)
  • Published : 2008.08.31
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Abstract

Herbal medicines are widely used to treat a variety of human diseases. However, therapeutic effect of herbal medicine on the canine facial nerve paralysis (FNP) has not been investigated. This study examined therapeutic effects of Oyaksungisan on the canine FNP. Ten dogs with the induced canine FNP were equally divided into the control and an herbal medicine-treated groups (5 dogs, Oyaksungisan-treated group), respectively. No treatment was given to the control group. In the Oyaksungisan-treated group, Oyaksungisan was administered orally, twice per day for 2 weeks (50 mg/kg) after inducing FNP. Significant differences in the clinical scores were detected between the Oyaksungisan-treated and control groups on day 14 (p < 0.05). The serum creatine kinase (CK) activities in the Oyaksungisan-treated group showed a tendency to decrease but there was no significant difference compared with those of the control group. In conclusion, Oyaksungisan was effective for the induced canine FNP.

한약제는 사람의 많은 질병의 치료를 위하여 사용되어 왔으나, 개 안면신경마비에 대한 한약제의 치료 효과는 현재까지 검토된 바 없다. 개 안면신경마비에 대한 오약순기산의 치료 효과를 조사하였다. 인공적으로 안면신경마비를 유발한 총 10두 대조군(5두)과 한약제 치료군(5두,오약순기산 치료군)으로 나누어 공시하였다. 대조군은 아무런 처치를 하지 않았으며,오약순기산 치료군은 1일 2회, 총 2주간 오약순기산(50 mg/kg)을 경구 투여하였다. 오약순기산 치료군의 임상 지표는 대조군에 비하여 14일(p<0.05)에 유의성 있는 개선을 보였다. 오약순기산 치료군의 혈청 CK 활성 변화는 대조군에 비하여 낮은 경향을 나타냈지만 유의성은 인정되지 않았다. 결론적으로, 오약순기산은 개 안면신경마비 치료에 유효한 것으로 판단되었다.

Keywords

References

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