The Plant Pathology Journal

The Korean Society of Plant Pathology (한국식물병리학회)
권호 표지
DOI QR코드

DOI QR Code

Antifungal Activity of the Methanol Extract of Myristica malabarica Fruit Rinds and the Active Ingredients Malabaricones Against Phytopathogenic Fungi

  • Choi, Nam-Hee (Bio-Control Research Team, Korea Research Institute of Chemical Technology) ;
  • Choi, Gyung-Ja (Bio-Control Research Team, Korea Research Institute of Chemical Technology) ;
  • Jang, Kyoung-Soo (Bio-Control Research Team, Korea Research Institute of Chemical Technology) ;
  • Choi, Yong-Ho (Bio-Control Research Team, Korea Research Institute of Chemical Technology) ;
  • Lee, Sun-Og (Bio-Control Research Team, Korea Research Institute of Chemical Technology) ;
  • Choi, Jae-Eul (College of Agricultural and Life Science, Chungnam National University) ;
  • Kim, Jin-Cheol (Bio-Control Research Team, Korea Research Institute of Chemical Technology)
  • Published : 2008.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

In a search for plant extracts with in vivo antifungal activity for plant diseases, we found that the methanol extract of Myristica malabarica fruit rinds effectively suppressed the development of several plant diseases. The methanol extract exhibited potent 1-day protective activity against rice blast, tomato late blight, wheat leaf rust and red pepper anthracnose. It also showed 7-day and 4-day protective activities against the plant diseases. Three antifungal resorcinols were isolated from the methanol extract of M. malabarica fruit rinds and identified as malabaricones A(MA), B(MB), and C(MC). Inhibitory activity of the three resorcinols against mycelial growth of plant pathogenic fungi varied according to compound and target species. All three compounds effectively reduced the development of rice blast, wheat leaf rust and red pepper anthracnose. In addition, MC was highly active for reducing the development of tomato late blight. This is the first report on the antifungal activities of malabaricones against filamentous fungi.

Keywords

References

  1. Choi, N. H., Kwon, H. R., Son, S. W., Choi, G. J., Choi, Y. H., Jang, K. S., Lee, S. O., Choi, J. E., Ngoc, L. H. and Kim, J.-C. 2008. Nematicidal activity of malabaricones isolated from Myristica malabarica fruit rinds against Bursaphelenchus xylophilus. Nematol. (in press)
  2. Khanom, F., Kayahara, H. and Tadasa, K. 2000. Superoxide-scavenging and prolyl endopeptidase inhibitory activities of Bangladeshi indigenous medicinal plants. Biosci. Biotechnol. Biochem. 64:837-840 https://doi.org/10.1271/bbb.64.837
  3. Kim, J.-C., Choi, G. J., Lee, S.-W., Kim, J.-S., Chung, K. Y. and Cho, K. Y. 2004. Screening for antifungal extracts against various plant pathogenic fungi and control of powdery mildew with extracts of Achyranthes japonica and Rumex crispus. Pest Manag. Sci. 60:803-808 https://doi.org/10.1002/ps.811
  4. Kim, J.-C., Choi, G. J., Park, J.-H., Kim, H. T. and Cho, K. Y. 2001. Activity against plant pathogenic fungi of phomalactone isolated from Nigrospora sphaerica. Pest Manag. Sci. 57:554-559 https://doi.org/10.1002/ps.318
  5. Kuo Y.-H., Lin, S.-T. and Wu, R.-E. 1989. Three new lignans from the nutmeg of Myristica cagayanesis. Chem. Pharm. Bull. 37:2310-2312 https://doi.org/10.1248/cpb.37.2310
  6. Morita, T., Jinno, K., Kawagishi, H., Arimoto, Y., Suganuma, H., Inakuma, T. and Sugiyama, K. 2003. Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/D-galactosamine-induced liver injury. J. Agric. Food Chem. 12:1560-1565
  7. Orabi, K. Y., Mossa, J. S. and El-Feraly, F. S. 1991. Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans). J. Nat. Prod. 54:856-859 https://doi.org/10.1021/np50075a017
  8. Patro, B. S., Bauri, A. K., Mishra, S. and Chattopadhyay, S. 2005. Antioxidant activity of Myristica malabarica extracts and their constituents. J. Agric. Food Chem. 53:6912-6918 https://doi.org/10.1021/jf050861x
  9. Pharm, V. C., Jossang, A., Sevenet, T. and Bodo, B. 2000. Cytotoxic acylphenols from Myristica maingayi. Tetrahedron 56:1707-1713 https://doi.org/10.1016/S0040-4020(00)00074-0
  10. Pharm, V. C., Jossang, A., Sevenet, T. and Bodo, B. 2002. Novel cytotoxic acylphenol dimmers of Myristica gigantean; enzymatic systhesis of giganteones A and B. Tetrahedron 58:5709-5714 https://doi.org/10.1016/S0040-4020(02)00537-9
  11. Sen, R., Bauri, A. K., Chattopadyay, S. and Chatterjee, M. 2007. Antipromastigote activity of the malabaricones of Myristica malabarica (rampatri). Phytother. Res. 21:592-595 https://doi.org/10.1002/ptr.2115
  12. Shinohara, C., Mori, S., Ando, T. and Tsuji, T. 1999. Arg-gingipain inhibition and anti-bacterial activity selective for Porphyromonas gingivilis by malabaricone C. Biosci. Biotechnol. Biochem. 63:1475-1477 https://doi.org/10.1271/bbb.63.1475
  13. Scannell, R. T., Barr, J. R., Murty, V. S., Reddy, K. S. and Hecht, S. M. 1988. DNA strand scission by naturally occurring 5-alkylresorcinols. J. Am. Chem. Soc. 110:3650-3651 https://doi.org/10.1021/ja00219a046

Cited by

  1. In Vivo Antifungal Activities of the Methanol Extracts of Invasive Plant Species Against Plant Pathogenic Fungi vol.28, pp.3, 2012, https://doi.org/10.5423/PPJ.NT.04.2012.0056
  2. Antimicrobial activity of several Brazilian medicinal plants against phytopathogenic bacteria vol.10, pp.17, 2016, https://doi.org/10.5897/AJMR2014.6999
  3. Antifungal activity of polyacetylenes isolated from Cirsium japonicum roots against various phytopathogenic fungi vol.34, pp.1, 2011, https://doi.org/10.1016/j.indcrop.2011.02.013
  4. Chemical Pesticides and Plant Essential Oils for Disease Control of Tomato Bacterial Wilt vol.28, pp.1, 2012, https://doi.org/10.5423/PPJ.OA.10.2011.0200
  5. Comparative Analysis of Extract ofPunica granatumvar.pleniflora(Golnar-e-farsi) to Some Antibiotics on Pathogens vol.18, pp.1, 2015, https://doi.org/10.1080/0972060X.2014.960272
  6. The effect of extract of Punica granatum var. pleniflora for treatment of minor recurrent aphthous stomatitis vol.3, pp.2, 2014, https://doi.org/10.1016/j.imr.2014.03.001
  7. WITHDRAWN: The effect of extract of Punica granatum var. pleniflora for treatment of minor recurrent aphthous stomatitis 2016, https://doi.org/10.1016/j.imr.2014.03.005
  8. Total Syntheses of Malabaricones B and C via a Cross-Metathesis Strategy vol.80, pp.6, 2017, https://doi.org/10.1021/acs.jnatprod.6b01119
  9. High potential of agro-industrial by-products of pomegranate (Punica granatum L.) as the powerful antifungal and antioxidant substances vol.34, pp.3, 2011, https://doi.org/10.1016/j.indcrop.2011.05.007