Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of a Novel Anthraquinone Diamino-Bridged Bis(β-cyclodextrin) and Its Cooperative Binding toward Guest Molecules

  • Zhao, Yan (College of Chemistry and Chemical Engineering, Yunnan Normal University) ;
  • Yang, Zi Ming (College of Chemistry and Chemical Engineering, Yunnan Normal University) ;
  • Chi, Shao Ming (College of Chemistry and Chemical Engineering, Yunnan Normal University) ;
  • Gu, Juan (College of Chemistry and Chemical Engineering, Yunnan Normal University) ;
  • Yang, Yong Cun (College of Chemistry and Chemical Engineering, Yunnan Normal University) ;
  • Huang, Rong (Experimental Center, Yunnan University) ;
  • Wang, Bang Jin (College of Chemistry and Chemical Engineering, Yunnan Normal University) ;
  • Zhu, Hong You (School of Chemical Science and Technology, Yunnan University)
  • Published : 2008.05.20
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Abstract

A novel anthraquinone diamino-bridged bis($\beta$ -cyclodextrin) 2 was synthesized. The inclusion complexation behaviors of the native $\beta$ -cyclodextrin 1 and the novel bis($\beta$ -cyclodextrin) 2 with guests, such as acridine red (AR), neutral red (NR), ammonium 8-anilino-1-naphthalenesulfonate (ANS), sodium 2-(p-toluidinyl) naphthalenesulfonate (TNS) and rhodamine B (RhB) were investigation by fluorescence, circular dichroism and 2D NMR spectroscopy. The spectral titrations were performed in phosphate buffer (pH 7.20) at 25 ${^{\circ}C}$ to give the complex stability constants (Ks) and Gibbs free energy changes (−${\Delta}G^0$) for the stoichiometric 1:1 inclusion complexation of host 1 and 2 with guests. The results indicated that the novel bis($\beta$ -cyclodextrin) 2 greatly enhanced the original binding affinity of the native $\beta$ -cyclodextrin 1. Typically, bis($\beta$ -cyclodextrin) 2 showed the highest binding constant towards ANS up to 34.8 times higher than that of 1. The 2D NMR spectra of bis($\beta$ -cyclodextrin) 2 with RhB and TNS were performed to confirm the binding mode. The increased binding affinity and molecular selectivity of guests by bis($\beta$ -cyclodextrin) 2 were discussed from the viewpoint of the size/shape-fit concept and multipoint recognition mechanism.

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