Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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The Effects of Chungkookjang Biopolymer on Blood Glucose and Serum Lipid Lowering in Streptozotocin-Induced Diabetic Rats

청국장 점질성 중합체의 첨가 식이가 Streptozotocin 유발 당뇨쥐의 혈당 및 혈청지질 감소에 미치는 영향

  • Kim, Seong-Ho (Dept. of Bio-Food Science, Kyongbuk College of Science) ;
  • Jung, So-Hyoung (Dept. of Bio-Food Science, Kyongbuk College of Science) ;
  • Kim, In-Ho (Kyongbuk College of Science Food Factory) ;
  • Lee, Yu-Soon (Division of Cosmetic Science, Kyongbuk College of Science) ;
  • Lee, Jin-Man (Dept. of Food and Biotechnology, Hoseo University) ;
  • Kim, Jong-Guk (Dept. of Microbiology, Kyungpook National University) ;
  • Lee, Myung-Chul (Division of Cell and Genetics, National Institute of Agricultural Biotechnology, Rural Development Administration) ;
  • Choi, Mi-Ja (Dept. of Food Nutrition, Keimyung University) ;
  • Kim, Duk-Jin (Division of Food Engineering and Nutrition, Daegu University)
  • 김성호 (경북과학대학 바이오식품과) ;
  • 정소형 (경북과학대학 바이오식품과) ;
  • 김인호 (경북과학대학 식품공장) ;
  • 이유순 (경북과학대학 화장품계열) ;
  • 이진만 (호서대학교 식품생물공학과) ;
  • 김종국 (경북대학교 미생물학과) ;
  • 이명철 (농촌진흥청 농업생명공학연구원 세포유전과) ;
  • 최미자 (계명대학교 식품영양학과) ;
  • 김덕진 (대구대학교 식품공학부)
  • Published : 2008.01.31
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Abstract

The purpose of this study was to investigate the effects of Chungkookjang viscous biopolymer supplementation on blood glucose and serum lipid-lowering in Streptozotocin (STZ)-induced diabetic rats. The rats were divided into three experimental groups; a normal group (N), diabetic control group (D), and a diabetic group with the supplementation of Chungkookjang viscous biopolymer (DCB). The groups were given experimental diets for four weeks. The normal group (C) was fed a casein-based diet, and the Chungkookjang viscous biopolymer group (DCB) received 3% biopolymer added to the casein-based diet. In the diabetic group (D), food intake increased significantly, but weight gain decreased significantly. The food efficiency ratio was significantly lower in the diabetic group. Liver weight increased significantly in the D group as compared to the N group. However, the DCB group showed a significant decrease in liver weight when compared to the D group. Blood glucose decreased significantly in the DCB group after receiving the experimental diet for four weeks, as compared to the diabetic control (p<0.05). Serum triglyceride levels were significantly lower in the DCB group than in the D group, whereas HDL-cholesterol levels were significantly higher (p<0.05). Total cholesterol was decreased in DCB group, but there were no significant differences. Also, LDL-cholesterol level was not significantly different among the experimental groups. Hepatic triglyceride and cholesterol were lower in the DCB group with no significant differences among groups. These results indicate that dietary supplementation of Chungkookjang viscous biopolymer improved glucose lowering and lipid metabolism in diabetic rats.

본 연구는 청국장 점질성 중합체의 첨가식이가가 STZ로 유발된 당뇨쥐의 혈당과 지질대사에 미치는 영향을 알아보고자 하였다. 실험동물은 정상군(N), 당뇨 유발군(D) 및 청국장 점질성 중합체 첨가식이 당뇨 유발군(DCB)으로 4주간 실험식이를 공급하였다. 체중증가량과 식이효율은 D군이 N군에 비해 유의적으로 낮았다. 간무게는 D군이 N군에 비해 유의적으로 높았으나 DCB군의 간무게는 D군에 비해 유의적으로 낮았다. D군의 혈당은 4주 동안 비슷한 범위를 유지하였으나 DCB군의 혈당은 실험 4주째에 D군에 비해 유의적으로 낮았다. 혈중 중성지방은 D군이 N군에 비해 유의적으로 높았다. 그러나 DCB군은 D군에 비해 유의적으로 낮았다. DCB군의 혈중 총콜레스테롤은 DM군에 비해 낮은 경향이었으나 유의적인 차이는 없었다. 혈중 HDL-콜레스테롤은 N군과 D군이 유의적인 차이가 없었으나 DCB군은 두 군에 비해 유의적으로 높았다. 혈중 LDL-콜레스테롤은 DCB군이 D군에 비해 낮은 경향이었으나 유의적인 차이는 없었다. 간의 중성지방 함량과 콜레스테롤 함량은 D군이 N군에 비해 유의적으로 높았으나 DCB군은 D군에 비해 낮은 경향이었다. 따라서 청국장 점질성 중합체의 첨가 식이는 STZ로 유발된 당뇨쥐의 혈당을 유의적으로 감소시켰으며 당뇨의 대표적인 합병증인 지질대사 이상 중 증가된 혈중 중성지방을 유의적으로 감소시켰으며 감소된 HDL-콜레스테롤을 유의적으로 증가시켰으므로 당뇨의 혈당조절과 고지혈증 개선에 유익할 것으로 사료된다.

Keywords

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