Journal of the Korean Society of Food Culture (한국식생활문화학회지)

Korean Society of Food Culture (한국식생활문화학회)
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Effect of Ecklonia cava on the Blood Glucose, Lipids and Renal Oxidative Stress in Diabetic Rats

당뇨쥐에서 감태의 혈당, 혈청지질 개선효과 및 신장의 항산화효과

  • Kim, Eun (Major in Food and Nutrition, Mokpo National University) ;
  • Kim, Min-Sook (Major in Food and Nutrition, Mokpo National University) ;
  • Kim, Se-Youn (Samkwang Medical Laboratories) ;
  • Kim, Hyeon-A (Major in Food and Nutrition, Mokpo National University)
  • 김은 (목포대학교 생활과학부 식품영양학) ;
  • 김민숙 (목포대학교 생활과학부 식품영양학) ;
  • 김세연 (삼광의료재단) ;
  • 김현아 (목포대학교 생활과학부 식품영양학)
  • Published : 2008.12.31
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Abstract

In this study, we assessed the effects of dietary supplementation with Ecklonia cava on blood glucose, lipid metabolism, and renal oxidative stress in streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were divided into a normal rat group fed on a control diet and diabetic rats fed on a control diet or supplemented with powder (15% w/w) or water extract of Ecklonia cava (2.5% w/w). Diabetes was induced by a single injection of STZ (60 mg/kg, ip) in citrate buffer. The animals were fed ad libitum with the experimental diet and water for 5 weeks. Dietary supplementation of Ecklonia cava powder and water extract was shown to reduce blood glucose levels in the diabetic rats, and the water extract was more effective than the powder. Dietary supplementation with Ecklonia cava also reduced LDL cholesterol and increased HDL-cholesterol levels in the diabetic rats. Renal glutathione S-transferase activity was increased in the diabetic rats as compared to the normal rats, but reverted to near control values as the result of dietary supplementation with Ecklonia cava. These results show that Eklonia cava exerts an anti-diabetic effect by improving blood glucose concentrations, LDL/HDL-cholesterol ratios, and antioxidative effects on the kidney in diabetic rats.

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References

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