한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제25권6호
  • /
  • Pages.523-525
  • /
  • 2008
  • /
  • 1598-298X(pISSN)
  • /
  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

Sertoli Cell Tumor Accompanied by Pancytopenia in a Dog

  • 발행 : 2008.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

11 year old male Yorkshire terrier was referred to Haemaru Referral Animal Hospital with signs of hematuria, petechia, and gynecomastia. Blood works revealed severe leukopenia, moderate anemia and severe thrombocytopenia. On ultrasonography and radiography, mixed echo texture mass was found in abdomen. The abdominal mass was surgically removed, and submitted for histopathology. Histopathologic features of the tissues were consistent with malignant Sertoli cell tumor. Bone marrow aspirates were hypocellular. Serum estrogen concentration was 72.80 pg/ml (normal range for females <15 pg/ml) after surgery. Clinical signs of feminization and hemorrhagic diathesis were attributed to hyperestrinism caused by the tumor. The dog was put on fluid therapy, antibiotics and palliative drugs and survived 2 more weeks after surgery without clinical improvement.

키워드

참고문헌

  1. MacLachlan NJ, Kennedy PC. Tumors of the Genital Systems. In: Moulton JE. Tumors in domestic animals. 4th ed. Berkeley: University of California Press. 2002: 561-567
  2. Hayes HM, Pendergrass TW. Canine testicular tumors: Epidemiological features of 410 dogs. Intl J Cancer 1976; 18: 482-487 https://doi.org/10.1002/ijc.2910180413
  3. Suess RP, Barr SC, Sacre BJ, French TW. Bone marrow hypoplasia in a feminized dog with an interstitial cell tumor. J Am Vet Med Assoc 1992; 200: 1346-1348
  4. Edwards DF. Bone Marrow hypoplasia in a feminized dog with a Sertoli cell tumor. J Am Vet Med Assoc 1981; 178: 494-496
  5. Sherding RG, Wilson GP, Kociba GJ. Bone Marrow Hypoplasia in Eight Dogs with Sertoli Cell Tumor. J Am Vet Med Assoc 1981; 178: 497-501
  6. Morgan RV. Blood Dyscrasias Associated with Testicular Tumors in the Dog. J Am Anim Hosp Assoc 1982; 18: 970-974
  7. Weiss DJ, Klausner JS. Drug-associated aplastic anemia in dogs: eight cases (1984-1988). J Am Vet Med Assoc 1990; 196: 472-475
  8. Weiss DJ, Christopher MM. Idiopathic aplastic anemia in a dog. Vet Clin Pathol 1985; 14: 23-25
  9. Brazzell J, Weiss D. A retrospective study of aplastic pancytopenia in the dog: 9 cases (1996-2003). Vet Clin Pathol 2006; 35: 413-417 https://doi.org/10.1111/j.1939-165X.2006.tb00157.x
  10. Sanpera N, Masot N, Janer M, Romeo C, de Pedro R. Oestrogen-induced bone marrow aplasia in a dog with a Sertoli cell tumour. J Small Anim Pract 2002; 43:365-369 https://doi.org/10.1111/j.1748-5827.2002.tb00087.x
  11. Mischke R, Meurer D, Hoppen HO, Ueberschar S, Hewicker-Trautwein M. Blood plasma concentrations of oestradiol-17$\beta$, testosterone and testosterone/oestradiol ratio in dogs with neoplastic and degenerative testicular diseases. Res Vet Sci 2002; 73: 267-272 https://doi.org/10.1016/S0034-5288(02)00100-5
  12. Hall EJ. Use of lithium for treatment of estrogen-induced bone marrow hypoplasia in a dog. J Am Vet Med Assoc 1992; 200: 814-816
  13. Maddux JM, Shaw SE. Possible beneficial effect of lithium therapy in a case of estrogen-induced bone marrow hypoplasia in a dog: a case report. J Am Anim Hosp Assoc 1983; 19: 242-245
  14. Dhaliwal RS, Kitchell BE, Knight BL, Schmidt BR. Treatment of Aggressive Testicular Tumours in Four Dogs. J Am Anim Hosp Assoc 1999; 35: 311-318 https://doi.org/10.5326/15473317-35-4-311