Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Protective Effect of Some Medicinal Plants on tert-Butyl Hydroperoxide-Induced Oxidative Stress in Human Keratinocytes

  • Published : 2008.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

It is well known that excessive production of reactive oxygen species (ROS) leads to oxidative stress, loss of cell function, and ultimately apoptosis or necrosis. To search for natural antioxidants able to modulate cellular oxidative stress, we investigated the protective effect of ethanol extracts of 17 medicinal plants selected from the preliminary antioxidant screening on tert-butyl hydroperoxide (t-BuOOH)-induced oxidative stress in human keratinocytes. The result showed that extracts of the four plants, Distylium racemosum, Astilbe chinensis, Cercis chinensis and Sapium japonicum, exhibited significant cytoprotective activity (over 50% protection) against t-BuOOH-induced cellular injury.

Keywords

References

  1. Bae, K.H., The Medicinal Plants of Korea. Kyo-Hak Publishing Co., Ltd, Seoul, pp. 204, 245, 427, 452, 2000
  2. Bandyopadhyay, U., Das, D., and Banerjee, R.K., Reactive oxygen species: oxidative damage and pathogenesis. Curr. Sci. 77, 658-666 (1999)
  3. Beal, M.F., Aging, energy and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357-366 (1995) https://doi.org/10.1002/ana.410380304
  4. Davies, M.J., Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with rat liver microsomal fractions. Biochem. J. 257, 603-606 (1989) https://doi.org/10.1042/bj2570603
  5. Fenglin, H., Ruili, L., Bao, H., and Liang, M., Free radical scavenging activity of extracts prepared from fresh leaves of selected Chinese medical plants. Fitoterapia 75, 14-23 (2004) https://doi.org/10.1016/j.fitote.2003.07.003
  6. Finkel, T. and Holbrook, N.J., Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247 (2000) https://doi.org/10.1038/35041687
  7. Frei, B., Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am. J. Med. 97, 5S-13S (1994) https://doi.org/10.1016/0002-9343(94)90292-5
  8. Holdsworth, D.K., Jones, R.A., and Self, R., Volatile alkaloids from Areca catechu. Phytochemistry 48, 581-582 (1998) https://doi.org/10.1016/S0031-9422(98)00016-8
  9. Ito, H., Kobayashi, E., Takamatsu, Y., Li, S.H., Hatano, T., Sakagami, H., Kusama, K., Satoh, K., Sugita, D., Shimura, S., Itoh, Y., and Yoshida, T., Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines. Chem. Pharm. Bull. 48, 687-693 (2000) https://doi.org/10.1248/cpb.48.687
  10. Kamiya, K., Yoshioka K., Saiki Y., Ikuta A., and Satake T., Triterpenoids and flavonoids from Paeonia lactiflora. Phytochemistry 44, 141-144 (1997) https://doi.org/10.1016/S0031-9422(96)00518-3
  11. Kang, S.J., Hong, S.S., Hwang, B.Y., Ro, J.S., Lee, K.S., and Towers, G.H.N, Phenolic compounds from the stems of Sapium japonicum. Nat. Prod. Sci. 12, 125-128 (2006)
  12. Kennedy, C.H., Church, D.F., Winston, G.W., and Pryor, W.A., tert-Butyl hydroperoxide-induced radical production in rat liver mitochondria. Free Radic. Biol. Med. 12, 381-387 (1992) https://doi.org/10.1016/0891-5849(92)90087-W
  13. Kobaisy, M., Tellez, M.R., Dayan, F.E., and Duke, S.O., Phytotoxicity and volatile constituents from leaves of Callicarpa japonica Thunb. Phytochemistry 61, 37-40 (2002) https://doi.org/10.1016/S0031-9422(02)00207-8
  14. Kwon, H.C., Choi, S.U., Lee, J.O., Bae, K.H., Zee, O.P., and Lee, K.R., Two new lignans from Lindera obtusiloba Blume. Arch. Pharm., Res., 22, 417-422 (1999) https://doi.org/10.1007/BF02979069
  15. Lin, H.C., Ding, H.Y., Wu, T.S., and Wu, P.L., Monoterpene glycosides from Paeonia suffruticosa. Phytochemistry 41, 237-242 (1996) https://doi.org/10.1016/0031-9422(95)00526-9
  16. Lu, Y. and Foo, L.Y., Polyphenolics of Salvia - A review. Phytochemistry 59, 117-1140 (2002) https://doi.org/10.1016/S0031-9422(01)00415-0
  17. Masaki, N., Kyle, M.E., and Farber, J.L., tert-Butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids. Arch. Biochem. Biophys. 269, 390-399 (1989) https://doi.org/10.1016/0003-9861(89)90122-7
  18. Maxwell, S.R.J., Prospects for the use of antioxidant therapies. Drugs 45, 345-361 (1995)
  19. Na, M., An, R.B., Lee, S.M., Hong, N.D., Yoo, J.K., Lee, C.B., Kim, J.P., and Bae, K.H., Screening of crude drugs for antioxidative activity. Kor. J. Pharmacogn. 32, 108-115 (2001)
  20. Na, M., An, R.B., Jin, W.Y., Min, B.S., Yoo, J.K., Kim, Y.H., and Bae, K.H., Antioxidant effects of plant extracts on free radicals and lipid peroxidation. Nat. Prod. Sci. 9, 226-231 (2003)
  21. Namba, T., The Encyclopedia of Wakan-Yaku (Traditional Sino-Japanese Medicines with Color Pictures Vol. I and II.. Hoikusha Publishing Co., Ltd, Osaka, pp. 300 (Vol. I), 102 (Vol. I), 132 (Vol. II), 216 (Vol. I), 80 (Vol. II), 239 (Vol. I), 1993
  22. Ngo, K.S. and Brown, G.D., Stilbenes, monoterpenes, diarylheptanoids, labdanes and chalcones from Alpinia katsumadai. Phytochemistry 47, 1117-1123 (1998) https://doi.org/10.1016/S0031-9422(97)00606-7
  23. O'Donnell, V. and Burkitt, M.J., Mitochondrial metabolism of a hydroperoxide to free radicals in human endothelial cells: an electron spin resonance spin-trapping investigation. Biochem. J. 304, 707-713 (1994) https://doi.org/10.1042/bj3040707
  24. Park, E.J., Zhao, Y.Z., Na, M., Bae, K.H., Kim, Y.H., Lee, B.H., and Sohn, D.H., Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or D-galactosamine-induced toxicity in rat primary hepatocytes. Planta Med. 69, 33-37 (2003a) https://doi.org/10.1055/s-2003-37027
  25. Park, Y., Lee, W.Y., Ahn, J.K., Lee, H.J., Chin, H.S., and Kwon, Y.J., Antioxidant compounds from Distylium racemosum leaves. Mokchae Konghak 31, 6-72 (2003b)
  26. Poulson, H.E., Preime, H., and Loft, S., Role of oxidative DNA damage in cancer initiation and promotion. Eur. J. Cancer Prev. 7, 9-16 (1998)
  27. Rana, V.S., Rawat, M.S.M., Pant, G., and Nagatsu, A., Chemical constituents and antioxidant activity of Mallotus roxburghianus leaves. Chem. Biodivers. 2, 792-798 (2005) https://doi.org/10.1002/cbdv.200590057
  28. Ruch, G.F., Gorski, J.R., Ripple, M.G., Sowinski, J., Bugelski, P., and Hewitt, W.R., Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes. Toxicol. App. Pharmacol. 78, 473- 483 (1985) https://doi.org/10.1016/0041-008X(85)90255-8
  29. Salatino, A., Salatino, M.L.F., and Giannasi, D.E., Flavonoids and the taxonomy of Cercis. Biochem. Syst. Ecol. 28, 545-550 (2000) https://doi.org/10.1016/S0305-1978(99)00093-9
  30. Silva, C.G., Herdeiro, R.S., Mathias, C.J., Panek, A.D., Silveira, C.S., Rodrigues, V.P., Renno, M.N., Falcao, D.Q., Cerqueira, D.M., and Minto, A.B.M., Evaluation of antioxidant activity of Brazilian plants. Pharm. Res. 52, 229-233 (2005) https://doi.org/10.1016/j.phrs.2005.03.008
  31. Tanaka, T., Jiang, Z.H., and Kouno, I., Distribution of ellagic acid derivatives and a diarylheptanoid in wood of Platycarya strobilacea. Phytochemistry 47, 851-854 (1998) https://doi.org/10.1016/S0031-9422(97)00670-5
  32. Timmins, G.S. and Davies, M.J., Free radical formation in isolated murine keratinocytes treated with organic peroxides and its modulation by antioxidants. Carcinogenesis 14, 1615-1620 (1993) https://doi.org/10.1093/carcin/14.8.1615
  33. Whang, W.K., Park, H.S., Ham, I.H., Oh, M., Namkoong, H., Kim, H.K., Hwang, D.W., Hur, S.Y., Kim, T.E., Park, Y.G., Kim, J.R., and Kim, J.W., Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress. Exp. Mol. Med. 37, 343-352 (2005) https://doi.org/10.1038/emm.2005.44
  34. Zhang, Z., Liao, L., Moore, J., Wu, T., and Wang, Z., Antioxidant phenolic compounds from walnut kernels (Juglans regia L.). Food Chem. 113, 160-165 (2009) https://doi.org/10.1016/j.foodchem.2008.07.061