Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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A Vinegar-processed Ginseng Radix (Ginsam) Ameliorates Hyperglycemia and Dyslipidemia in C57BL/KsJ db/db Mice

  • Han, Eun-Jung (Pharmacology and Clinical Pharmacy Lab, College of Pharmacy, Kyung Hee University) ;
  • Park, Keum-Ju (Pharmacology and Clinical Pharmacy Lab, College of Pharmacy, Kyung Hee University) ;
  • Ko, Sung-Kwon (Department of Oriental Medical Food and Nutrition, Semyung University) ;
  • Chung, Sung-Hyun (Pharmacology and Clinical Pharmacy Lab, College of Pharmacy, Kyung Hee University)
  • Published : 2008.12.31
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Abstract

Having idea to develop more effective anti-diabetic agent from ginseng root, we comprehensively assessed the anti-diabetic activity and mechanisms of ginsam in C57BL/KsJ db/db mice. The db/db mice were divided into 4 groups; diabetic control (DC), ginsam at a dose of 300 or 500 mg/kg (GS300 or GS500) and metformin at a dose of 300 mg/kg (MT300). Ginsam was orally administered for 8 weeks. GS500 reduced the blood glucose concentration and significantly decreased an insulin resistance index. In addition, GS500 reduced the plasma non-esterified fatty acid, triglyceride, and increased high density lipoprotein-cholesterol as well as decreased the hepatic cholesterol and triglyceride. More interestingly, ginsam increased the plasma adiponectin level by 17% compared to diabetic control group. Microarray, quantitative-polymerase chain reaction and enzyme activity results showed that gene and protein expressions associated with glycolysis, gluconeogenesis, and fatty acid oxidation were changed to the way of reducing hepatic glucose production, insulin resistance and enhancing fatty acid $\beta$-oxidation. Ginsam also increased the phosphorylation of AMP-activated protein kinase and glucose transporter expressions in the liver and skeletal muscle, respectively. These changes in gene expression were considered to be the mechanism by which the ginsam exerted the anti-diabetic and anti-dyslipidemic activities in C57BL/KsJ db/db mice.

Keywords

References

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