Journal of Korean Society of Industrial and Systems Engineering (산업경영시스템학회지)

Society of Korea Industrial and System Engineering (한국산업경영시스템학회)
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Micro Robotic Suspended Cell Injection System for Automatic Batch Bio-manipulation

통합 자동화 세포 조작을 위한 마이크로 로보틱 서스펜디드 셀 연젝션 시스템

  • Kim, Seung-Min (Mechatronics Examination Team, Korean Intellectual Property Office) ;
  • Huang, Haibo (Department of Mechanical and Industrial Engineering, University of Toronto) ;
  • Nahm, Yoon-Eui (Department of Mechanical Design Engineering, Hanbat National University)
  • 김성민 (특허청 제어기계심사팀) ;
  • ;
  • 남윤의 (한밭대학교 기계설계공학과)
  • Published : 2008.12.31
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Abstract

생물학적인 셀 인젝션 기술은 유전자 주입, 시험관 배양, 인공수정 및 신약개발 분야에서 광범위하게 사용되어 오고 있는 기술이다. 생물공학에서 다루는 셀 인젝션 기술은 크게 착생세포 인젝션과 서스펜디드 셀 인젝션으로 구분할 수 있다. 최근 상용화 장비로 출시되고 있는 것들은 착생세포에 대한 자동 인젝션 시스템이 대부분을 차지하고 있다. 반면, 서스펜디드 셀 인젝션 시스템의 경우는 비교적 최근들어 자동화 장비 및 방법론의 개발에 대한 논의가 이루어지고 있는 실정으로 실제 수많은 연구자들의 노력에 힘입어 서스펜디드 셀을 대상으로 한 통합 자동화 셀 인젝션 시스템의 개발이 가속화되고 있기는 하지만 이에 대한 만족할 만한 성과는 아직 이루어 지지 않고 있는 실정이다. 본 논문은 서스펜디드 셀을 대상으로 한 인젝션 시스템 개발에 관한 것으로 특히 셀 홀딩 시스템과 최적의 인젝션 피펫 궤적을 결정하기 위한 시스템 개발에 관한 것이다. 본 논문에서 다루어지는 서스펜디드 셀은 통합 자동화를 위하여 특별히 고안된 셀홀딩 시스템에 의하여 배열의 형태로 고정되며, 셀 인젝션 시스템은 엠브리오와 인젝션 피켓을 이미지 프로세싱 기술에 의하여 인식하고 피펫의 인젝션 궤적을 결정하는 것을 포함하고 있다.

Keywords

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