Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity

고지방 식이 유도 비만에 대한 대시호탕 추출물의 억제 효과

  • Song, Mi-Young (Dept. of Biochemistry, Medical School and Institute for Medical Sciences, Chon-Buk National University) ;
  • Kim, Eun-Kyung (Dept. of Biochemistry, Medical School and Institute for Medical Sciences, Chon-Buk National University) ;
  • Kong, Jae-Cheol (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Lee, Jeong-Han (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Shin, Byung-Cheul (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Ryu, Do-Gon (Dept. of Physiology, College of Oriental Medicine, Won-Kwang University) ;
  • Kwon, Kang-Beom (Dept. of Physiology, College of Oriental Medicine, Won-Kwang University)
  • 송미영 (전북대학교 의과대학 생화학교실) ;
  • 김은경 (전북대학교 의과대학 생화학교실) ;
  • 공재철 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 이정한 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 신병철 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 류도곤 (원광대학교 한의과대학 한방생리학교실) ;
  • 권강범 (원광대학교 한의과대학 한방생리학교실)
  • Received : 2008.06.16
  • Accepted : 2008.07.14
  • Published : 2008.07.31

Abstract

Objectives : The aim of this study is to investigate Daesiho-tang(Dachaihu-tang) water extracts (DSTE) have potent anti-obesity activities in a high-fat diet-induced obesity mouse model. Methods : In this study, we designed three groups (normal diet group, high-fat diet group, high-fat diet plus DSTE group for 7-weeks oral administration). Results : Increases in body weight were inhibited by 7-weeks oral administration of DSTE at a 500 mg/kg concentration in this animal model. Results from blood lipid analysis showed that the levels of triglyceride, total cholesterol and LDL-cholesterol were significantly lowered by DSTE administration, also HDL-cholesterol was increased more than high-fat diet-induced obese mouse. To understand the underlying mechanism at the molecular level, the effects of DSTE were examined on the expression of the genes involved in lipogenesis by real-time PCR. In epididymal fat and liver of DSTE-treated mice, the mRNA level of lipogenic genes such as sterol regulatory element binding protein 1 and fatty acid synthase were decreased, which was well correlated with the reduction of the tissues weight. Conclusions : These results suggest that DSTE may have great potential as a novel anti-obesity agent.

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Acknowledgement

Supported by : 한국학술진흥재단