Influence of Occupational Exposure to Bisphenol A on the Sex Hormones of Male Epoxy Resin Painters

  • Cha, Bong-Suk (Department of Preventive Medicine, Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine) ;
  • Koh, Sang-Baek (Department of Preventive Medicine, Institute of Life Long Health, Yonsei University Wonju College of Medicine) ;
  • Park, Jun-Ho (Department of Preventive Medicine, Institute of Life Long Health, Yonsei University Wonju College of Medicine) ;
  • Eom, Ae-Yong (Department of Nursing, Margaret Prtchard University) ;
  • Lee, Kang-Myeung (Department of Preventive Medicine, Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine) ;
  • Choi, Hong-Soon (Institute of Occupational and Environmental Health, Kwandong University)
  • Published : 2008.09.30

Abstract

Epidemiological studies demonstrate an adverse effect of several environmental and occupational exposures on male sex hormone. Bisphenol A (BPA) is a weak estrogen and a widely used industrial chemical. Epoxy resin painters may be continuously exposed to BPA at high concentrations. The effect of occupational exposure of BPA on male reproduction was examined by measuring the urinary BPA, testosterone and gonadotropic hormones of epoxy resin painters in the shipyard. The painters had significantly higher concentrations of urinary BPA (2.61${\pm}$1.08 ${\mu}g$/g creatinine) than controls (1.38${\pm}$0.5 9 ${\mu}g$/g creatinine). In serum, the testosterone level of painters was significantly decreased but the luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels of painters were significantly higher than controls. Occupational exposure to BPA influences testosterone and gonadotropic hormones in male workers.

References

  1. The Worldwide News Sources for Chemical Makers and Processors. Chemical Week. 2005 (online), available from , (accessed 2007. 1. 11)
  2. Volkel, W. et al. Metabolism and kinetics of bisphenol A in human at low doses following oral administration. Chem Res Toxicol 15:1281-1287 (2005) https://doi.org/10.1021/tx025548t
  3. Krishnan, A. V. et al. Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132:2279-2286 (1993) https://doi.org/10.1210/en.132.6.2279
  4. Steinmetz, R. et al. The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo. Endocrinology 138:1780-1786 (1997) https://doi.org/10.1210/en.138.5.1780
  5. Gaido, K. W. et al. Evaluation of chemicals with endocrine midulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol Appl Pharmacol 143: 205-212 (1997) https://doi.org/10.1006/taap.1996.8069
  6. Villalobos, M. et al. The E-Screen assay: a comparison of different MCF-7 cell stocks. Environ Health Perspect 103:844-850 (1995) https://doi.org/10.2307/3432398
  7. Pottenger, L. H. et al. The relative bioavailability and metabolism of bisphenol A in rats dependent upon the route of administration. Toxicol Sci 54:3-18 (2000) https://doi.org/10.1093/toxsci/54.1.3
  8. Matthews, J. B., Twomey, K. & Zacharewski, T. R. In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors $\alpha$ and $\beta$. Chem Res Toxicol 14:149-157 (2001) https://doi.org/10.1021/tx0001833
  9. Snyder, R. W. et al. Metabolism and disposition of bisphenol A in female rats. Toxicol Appl Pharmacol 168:225-234 (2000) https://doi.org/10.1006/taap.2000.9051
  10. Akingbemi, B. T. et al. Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenetic enzyme gene expression in rat Leydig cells. Endocrinology 145:592-603 (2004) https://doi.org/10.1210/en.2003-1174
  11. Hanaoka, T., Kawamura, N., Hara, K. & Tsugane, S. Urinary bisphenol A and plasma hormone concentrations in male workers exposed to bisphenol A diglycidyl ether and mixed organic solvents. Occup Environ Med 59:625-628 (2002) https://doi.org/10.1136/oem.59.9.625
  12. Matsumoto, A. et al. Bisphenol A levels in human urine. Environ Health Perspectives 11:101-104 (2003) https://doi.org/10.2307/3428331
  13. Carlsen, E., Giwercman, A., Keiding, N. & Skakkebaek, N. E. Evidence for decreasing quality of semen during past 50 years. Br Med J 305:609-613 (1992) https://doi.org/10.1136/bmj.305.6854.609
  14. Winker, R. & Rudiger, H. W. Reproductive toxicology in occupational settings. Int Arch Occup Environ Health 79:1-10 (2006) https://doi.org/10.1007/s00420-005-0011-5
  15. Vom Saal, F. S. et al. A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior. Toxicol Ind Health 14:239-260 (1998) https://doi.org/10.1177/074823379801400115
  16. Gupta, C. Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals. Proc Soc Exp Biol Med 224:61-68 (2000)
  17. Ramos, J. G. et al. Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate. Biol Reprod 65:1271-1277 (2001) https://doi.org/10.1095/biolreprod65.4.1271
  18. Herath, C. B. et al. Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats. Endocrine 25:163-172 (2004) https://doi.org/10.1385/ENDO:25:2:163
  19. Tohei, A., Suda, S., Hashimoto, T. & Kogo, H. Bisphenol A inhibits testicular functions and increased luteinizing hormone secretion in adult male rats. Exp Biol Med 226:216-221 (2001) https://doi.org/10.1177/153537020122600309
  20. Evans, N. P., North, T., Dye, S. & Sweeney, T. Differential effects of the endocrine-disrupting compounds bisphenol-A and octylphenol on gonadotropin secretion, in prepubertal ewe lambs. Domest Anim Endocrinol 26:61-73 (2004) https://doi.org/10.1016/j.domaniend.2003.09.005
  21. Luderer, U. et al. Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men. Am J Ind Med 46:614-626 (2004) https://doi.org/10.1002/ajim.20100
  22. Morck, H. I. et al. Health effects of toluene exposure. Dan Med Bull 35:196-200 (1998)
  23. Calafat, A. M. et al. Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environmental Health Perspective 113:391-395 (2005) https://doi.org/10.1289/ehp.7534