YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Cell Regenerative Effect of Benzoic Acid Derivatives Against Chomium Trioxide-Induced Cytotoxicity

벤조산 유도체의 Chromium Trioxide 독성에 대한 세포 재생효과

  • Han, Du-Seok (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Choi, Byung-Nam (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Lee, Jae-Sug (Department of Beauty Science, Kwangju Wonmen's University) ;
  • Choi, Hwa-Jung (Natural Medicine Research Centre, Korea Research Institute of Bioscience & Biotechnology) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional School of Oriental Medicine, Wonkwang University)
  • 한두석 (원광대학교 치과대학 구강해부학교실) ;
  • 최병남 (원광대학교 치과대학 구강해부학교실) ;
  • 이재숙 (광주여자대학교 미용과학과) ;
  • 최화정 (생명공학연구원 천연의학연구부) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2008.10.31
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Abstract

In order to evaluate the cytotoxicity of chromium trioxide, and the cell regenerative effect of phenolic acid against chromium trioxide-induced cytotoxicity, cell viability, cell adhesion activity, lactate dehydrogenase (LDH) activity, and morphological changes of cells were performed in these cultures. The toxicity of chromium trioxide (${IC}_{50}$, 44.0 ${\mu}M$) was high according to the toxic criteria. Cell regeneration of benzoic acid derivatives against ${IC}_{50}$ value of chromium trioxide in cell morphology was increased in concentration-dependent manner. These results suggest that benzoic acid derivatives may be used as a cell regenerative agent against chromium-mediated cytotoxicity.

Keywords

References

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