대한임상독성학회지 (Journal of The Korean Society of Clinical Toxicology)

  • 제6권1호
  • /
  • Pages.1-8
  • /
  • 2008
  • /
  • 1738-1320(pISSN)
  • /
  • 2508-6332(eISSN)
대한임상독성학회 (Korean society of Clincal Toxicology)
권호 표지

아세트아미노펜 중독

Acetaminophen Poisoning

  • 정성필 (연세대학교 의과대학 응급의학과) ;
  • 김승호 (연세대학교 의과대학 응급의학과) ;
  • 이한식 (연세대학교 의과대학 응급의학과)
  • Chung, Sung-Pil (Department of Emergency Medicine, Yonsei University College of Medicine) ;
  • Kim, Seung-Ho (Department of Emergency Medicine, Yonsei University College of Medicine) ;
  • Lee, Hahn-Shick (Department of Emergency Medicine, Yonsei University College of Medicine)
  • 발행 : 2008.06.12
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초록

Acetaminophen (AAP) overdose can result in potentially serious hepatotoxicity. The ingested dose and time from ingestion to presentation are important prognostic factors. Toxic dose in adult is thought to be at least 10 g or 200 mg/kg. However, early management of acute overdose should be guided by the plasma AAP concentration. The antidote for AAP poisoning is N-acetylcysteine (NAC). It provides complete protection against hepatotoxicity if given within 8 h of acute overdose. If the concentration is above the possible toxicity line as predicted by the Rumack-Matthew nomogram, either the 72-hr oral or the 20-hr intravenous NAC regimen should be administered. NAC is also effective if started late in patients with established hepatic failure. This article summarizes the current consensus of clinical assessment and management for acute AAP overdose.

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