DOI QR코드

DOI QR Code

Corticosterone Administration Alters Small Intestinal Morphology and Function of Broiler Chickens

  • Hu, Xiaofei (State Key Labo ratory of Animal Nutrition, College of Animal Science and Technology China Agricultural University) ;
  • Guo, Yuming (State Key Labo ratory of Animal Nutrition, College of Animal Science and Technology China Agricultural University)
  • 투고 : 2008.03.17
  • 심사 : 2008.05.26
  • 발행 : 2008.12.01

초록

Two experiments were carried out to study the effects of corticosterone (CORT) administration on intestinal morphology and function of broilers. In both experiments, birds were randomly divided into two equal groups. One group was the control group (CTRL), and the birds were fed with a basal diet. The other was the experimental group (CORT), and the birds were fed with the basal diet plus 30 mg of CORT/kg diet. At 21 days of age, performance, morphological characteristics of intestine, D-xylose level in plasma, activities of digestive enzymes in digesta, digestibility of nutrients and 5-bromo-2-deoxyuridine (BrdUrd)-labeling index of intestinal epithelial cells were determined. CORT administration decreased feed intake, daily gain and feed conversion ratio (p<0.05). CORT also decreased duodenal and jejunal villus height (p<0.05) as well as crypt depth (p<0.05). The D-xylose level in plasma of CORT-treated broilers was lower than that of the control (p<0.05). CORT treatment caused a decrease in apparent digestibility of protein (p<0.05), whereas fat and starch apparent digestibilities were unaffected (p>0.05). CORT administration increased activities of trypsin and amylase (p<0.05), and decreased BrdUrd-labeling index of duodenal and jejunal epithelial cells (p<0.05). In conclusion, CORT administration impaired the normal morphology and absorptive capacity of the small intestine of broiler chickens.

키워드

참고문헌

  1. Covasa, M. and J. M. Forbes. 1995. Selection of foods by broiler chickens following corticosterone administration. Br. Poult. Sci. 36:489-501. https://doi.org/10.1080/00071669508417794
  2. Daniel, H. 2004. Molecular and integrative physiology of intestinal peptide transporter. Annu. Rev. Physiol. 66:361-384. https://doi.org/10.1146/annurev.physiol.66.032102.144149
  3. Doerfler, R. E., L. D. Cain, F. W. Edens, C. R. Parkhurst, M. A. Qureshi and G. B. Havenstein. 2000. D-Xylose absorption as a measurement of malabsorption in poultry enteritis and mortality syndrome. Poult. Sci. 79:383-390. https://doi.org/10.1093/ps/79.3.383
  4. Eid, Y. Z., A. Ohtsuka and K. Hayashi. 2003. Tea polychenols reduce glucocorticoid-induced growth inhibition and oxidative stress in broiler chickens. Br. Poult. Sci. 44:127-132. https://doi.org/10.1080/0007166031000085427
  5. Gal-Garber, O., S. J. Mabjeesh, D. Sklan and Z. Uni. 2000. Partial sequence and expression of the gene forand activity of the sodium glucose transporter in the small intestine of fed, starved and refed chickens. J. Nutr. 130:2174-2179. https://doi.org/10.1093/jn/130.9.2174
  6. Hediger, M. A. and D. B. Rhoads. 1994. Molecular physiology of sodium-glucose cotransporters. Physiol. Rev. 74:993-1026. https://doi.org/10.1152/physrev.1994.74.4.993
  7. Helrich, K. 1990. Official methods of analysis of the association of official analytical chemists. 15thed. Association of Official Analytical Chemists, Inc., Arlington, Virginia, USA. pp. 69-83.
  8. Howard, T., R. A. Goodlad, J. R. F. Walters, D. Ford and B. H. Hirst. 2004. Increased expression of specific intestinal amino acid and Peptide transporter mRNA in rats fed by TPN is reversed by GLP-2. J. Nutr. 134:2957-2964. https://doi.org/10.1093/jn/134.11.2957
  9. Iji, P. A., A. Saki and D. R. Tivey. 2001. Body and intestinal growth of broiler chicks on a commercial starter diet. 1. Intestinal weight and mucosal development. Br. Poult. Sci. 42:505-513. https://doi.org/10.1080/00071660120073151
  10. Lin, H., E. Decuypere and J. Buyse. 2004. Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus) 1. Chronic exposure. Comp. Biochem. Physiol. 139B:737-744.
  11. Malheiros, R. D., V. M. B. Moraes, A. Collin, E. Decuypere and J. Buyse. 2003. Free diet selection by broilers as influenced by dietary macronutrient ratio and corticosterone supplementation. 1. Diet selection, organ weights, and plasma metabolites. Poult. Sci. 82:123-131. https://doi.org/10.1093/ps/82.1.123
  12. Mitchell, M. A. and A. J. Carlisle. 1992. The effect of chronic exposure to elevated environmental temperature on intestinal morphology and nutrient absorption in the domestic fowl (Gullus domesticus). Comp. Biochem. Physiol. 101A:137-142.
  13. Moberg, G. P. and J. A. Mench. 2000. The biology of animal stress: basic principles and implications for animal welfare. CABI Publishing, Wallingford, UK, New Yourk, NY, USA. pp.3-6.
  14. Nasir, A., R. P. Moudgal and N. B. Singh. 1999. Involvement of corticosterone in food intake, food passage time and in vivo uptake of nutrients in the chicken (Gallus domesticus). Br. Poult. Sci. 40:517-522. https://doi.org/10.1080/00071669987296
  15. Ogihara, H., T. Suzuki, Y. Nagamachi, K. I. Inui and K. Takata. 1999. Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acid. Histochem. J. 31:169-174. https://doi.org/10.1023/A:1003515413550
  16. Osman, A. M. 1982. Amylase in chicken intestine and pancreas. Comp. Biochem. Physiol. 73B:571-574.
  17. Pinheiro, D. F., V. C. Cruz, J. R. Sartori and M. L. M. Vicentini Paulino. 2004. Effect of early feed restriction and enzyme supplementation on digestive enzyme activities in broilers. Poult. Sci. 83:1544-1550. https://doi.org/10.1093/ps/83.9.1544
  18. Post, J., J. M. J. Rebel and A. A. H. M. ter Huurne. 2003. Physiological effects of elevated plasma corticosterone concentrations in broiler chickens. An alternative means by which to assess the physiological effects of stress. Poult. Sci. 82:1313-1318. https://doi.org/10.1093/ps/82.8.1313
  19. Puvadolpirod, S. and J. P. Thaxton. 2000a. Model of physiological stress in chickens 2. Dosimetry of adrenocorticotropin. Poult. Sci. 79:370-376. https://doi.org/10.1093/ps/79.3.370
  20. Puvadolpirod, S. and J. P. Thaxton. 2000b. Model of physiological stress in chickens 4. Digestion and metabolism. Poult. Sci. 79:383-390. https://doi.org/10.1093/ps/79.3.383
  21. Spratt, R. S., B. W. McBride, H. S. Bayley and S. Leeson. 1990. Energy metabolism of broiler breeder hens. 2. Contribution of tissues to total heat production in fed and fasted hens. Poult. Sci. 69:1348-1356. https://doi.org/10.3382/ps.0691348
  22. Thoolen, B. O. B. 1990. BrdUrd labeling of s-phase cells in tests and small intestine of mice, using microwave irradiation for immunogold-silver staining: an immunocytochemical study. J. Histochem. Cytochem. 38:267-273. https://doi.org/10.1177/38.2.1688900
  23. Tietz, N. W. and E. A. Fiereck. 1966. A specific method for serum lipase determination. Clin. Chim. Acta 13:352-358. https://doi.org/10.1016/0009-8981(66)90215-4
  24. Uni, Z., S. Ganot and D. Sklan. 1998. Post-hatch development of mucosal function in the broiler small intestines. Poult. Sci. 77:75-82. https://doi.org/10.1093/ps/77.1.75
  25. Uni, Z., O. Gal-Garber, A. Geyra, D. Sklan and S. Yahav. 2001. Change in growth and function of chick small intestine epithelium due to early thermal conditioning. Poult. Sci. 80:438-445. https://doi.org/10.1093/ps/80.4.438
  26. Virden, W. S., M. S. Lilburn, J. P. Thaxton, A. Corzo, D. Hoehler and M. Kidd. 2007. The effects of corticosterone-induced stress on amino acid digestibility in Ross broilers. Poult. Sci. 86:338-342. https://doi.org/10.1093/ps/86.2.338
  27. Weisiger, R. A. 1996. Cytoplasmic transport of lipid: role of binding proteins. Comp. Biochem. Physiol. 115B:319-331.
  28. Yamauchi, K., H. Kamisoyama and Y. Isshiki. 1996. Effects of fasting and refeeding on structures of the intestinal villus and epithelial cell in White Leghorn hens. Br. Poult. Sci. 37:909-921. https://doi.org/10.1080/00071669608417922
  29. Yamauchi, K. and P. Tarachai. 2000. Change in intestinal villus, cell area and intracellular autophagic vacuoles related to intestinal function in chickens. Br. Poult. Sci. 41:116-123.
  30. Yang, Y., P. A. Iji and M. Choct. 2007. Effects of different dietary levels of mannanoligosaccharide on growth performance and gut development of broiler chickens. Asian-Aust. J. Anim. Sci. 20:1084-1091. https://doi.org/10.5713/ajas.2007.1084
  31. Yuan, J., J. Yao, F. Yang, X. Yang, X. Wan, J. Han, Y. Wang, X. Chen, Y. Liu, Z. Zhou, N. Zhou and X. Feng. 2008. Effects of supplementing different levels of a commercial enzyme complex on performance, nutrient availability, enzyme activity and gut morphology of broilers. Asian-Aust. J. Anim. Sci. 21:692-700. https://doi.org/10.5713/ajas.2008.70375
  32. Ziegler, T. R., M. E. Evans, F. E. Concepcion and D. P. Jones. 2003. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. Annu. Rev. Nutr. 23:229-261. https://doi.org/10.1146/annurev.nutr.23.011702.073036

피인용 문헌

  1. Forsythia suspensa extract attenuates corticosterone-induced growth inhibition, oxidative injury, and immune depression in broilers vol.93, pp.7, 2014, https://doi.org/10.3382/ps.2013-03772
  2. Micro-encapsulated sodium butyrate attenuates oxidative stress induced by corticosterone exposure and modulates apoptosis in intestinal mucosa of broiler chickens vol.55, pp.5, 2015, https://doi.org/10.1071/AN13348
  3. Comprehensive growth performance, immune function, plasma biochemistry, gene expressions and cell death morphology responses to a daily corticosterone injection course in broiler chickens vol.12, pp.2, 2017, https://doi.org/10.1371/journal.pone.0172684
  4. Effect of Chromium Nanoparticles on Physiological Stress Induced by Exogenous Dexamethasone in Japanese Quails pp.1559-0720, 2018, https://doi.org/10.1007/s12011-017-1192-y
  5. Cloning of oligopeptide transport carrier PepT1 and comparative analysis of PepT1 messenger ribonucleic acid expression in response to dietary nitrogen levels in yak (Bos grunniens) and indigenous cattle (Bos taurus) on the Qinghai–Tibetan plateau1 vol.94, pp.8, 2016, https://doi.org/10.2527/jas.2016-0501
  6. Effects of Acute Cold Stress After Long-Term Cold Stimulation on Antioxidant Status, Heat Shock Proteins, Inflammation and Immune Cytokines in Broiler Heart vol.9, pp.1664-042X, 2018, https://doi.org/10.3389/fphys.2018.01589
  7. Comparison of growth performance and immune responses of broiler chicks reared under heat stress, cold stress and thermoneutral conditions vol.16, pp.2, 2018, https://doi.org/10.5424/sjar/2018162-12753
  8. Effect of Corticosterone Administration on Small Intestinal Weight and Expression of Small Intestinal Nutrient Transporter mRNA of Broiler Chickens vol.23, pp.2, 2008, https://doi.org/10.5713/ajas.2010.90281
  9. Effect of supplementation of prebiotic mannan-oligosaccharides and probiotic mixture on growth performance of broilers subjected to chronic heat stress vol.91, pp.9, 2012, https://doi.org/10.3382/ps.2012-02182
  10. Growth performance and intestinal morphology in broiler chickens produced from hyperthyroid breeder hens vol.53, pp.10, 2013, https://doi.org/10.1071/an12302
  11. Steering Endogenous Butyrate Production in the Intestinal Tract of Broilers as a Tool to Improve Gut Health vol.2, pp.None, 2015, https://doi.org/10.3389/fvets.2015.00075
  12. Effect of Dietary Lead on Intestinal Nutrient Transporters mRNA Expression in Broiler Chickens vol.2015, pp.None, 2008, https://doi.org/10.1155/2015/149745
  13. Omega-3 fatty acids reduce the negative effects of dexamethasone-induced physiological stress in laying hens by acting through the nutrient digestibility and gut morphometry vol.100, pp.3, 2008, https://doi.org/10.1016/j.psj.2020.12.002
  14. Overview of the Use of Probiotics in Poultry Production vol.11, pp.6, 2008, https://doi.org/10.3390/ani11061620
  15. Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (Gallus gallus domesticus) vol.11, pp.11, 2008, https://doi.org/10.3390/ani11113276