Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Dysmyelopoiesis in a cat with immune-mediated hemolytic anemia

  • Yu, Do-Hyeon (College of Veterinary Medicine & Bio-Safety Institute, Chonbuk National University) ;
  • Lee, Jong-Hyun (College of Veterinary Medicine & Bio-Safety Institute, Chonbuk National University) ;
  • Yoon, Ji-Seon (College of Veterinary Medicine & Bio-Safety Institute, Chonbuk National University) ;
  • Li, Ying-Hua (College of Veterinary Medicine & Bio-Safety Institute, Chonbuk National University) ;
  • Lee, Mi-Jin (College of Veterinary Medicine & Bio-Safety Institute, Chonbuk National University) ;
  • Park, Jinho (College of Veterinary Medicine & Bio-Safety Institute, Chonbuk National University)
  • Accepted : 2008.04.15
  • Published : 2008.08.01
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Abstract

A 3-year-old spayed female Persian feline with non regenerative anemia showed persistent autoagglutination in EDTA anticoagulated blood. Primary immune-mediated hemolytic anemia (IMHA) was suspected and the underlying causes for IMHA were excluded by radiologic, sonographic, serologic and molecular studies. Cytologic examination of the bone marrow revealed that dysmyelopoiesis and dysplastic changes were prominent in the erythroid cells. These changes included asynchronous maturation of the nucleus and cytoplasm, binucleation, trinucleation, fragmented or lobulated nuclei and multilineages. Mild dysgranulopoiesis and dysmegakaryocytopoiesis were also detected including pseudo Pelger-Huet anomalies, giant band neutrophils, asynchronous maturation of the nucleus and cytoplasm in granulopoiesis and large hypolobulated forms as well as dwarf megakaryocytes in megakaryocytopoiesis. Myelodysplastic syndrome and congenital dysmyelopoiesis was ruled out by the low number of blast cells. Finally, secondary dysmyelopoiesis associated with IMHA was diagnosed and immunosuppressive treatment was successfully responsive.

Keywords

References

  1. Arjona A, Barquero N, Domenech A, Tejerizo G, Collado VM, Toural C, Martin D, Gomez-Lucia E. Evaluation of a novel nested PCR for the routine diagnosis of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV). J Feline Med Surg 2007, 9, 14-22
  2. Jacobs G, Calvert C, Kaufman A. Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants. J Am Vet Med Assoc 1998, 212, 681-684
  3. Kohn B, Weingart C, Eckmann V, Ottenjann M, Leibold W. Primary immune-mediated hemolytic anemia in 19 cats: diagnosis, therapy, and outcome (1998-2004). J Vet Intern Med 2006, 20, 159-166 https://doi.org/10.1892/0891-6640(2006)20[159:PIHAIC]2.0.CO;2
  4. Miescher PA, Favre H, Beris P. Autoimmune myelodysplasia. Semin Hematol 1991, 28, 322-330
  5. Switzer JW, Jain NC. Autoimmune hemolytic anemia in dogs and cats. Vet Clin North Am Small Anim Pract 1981, 11, 405-420 https://doi.org/10.1016/S0195-5616(81)50036-2
  6. Schuetz TJ, Stone RM. Myelodysplastic syndromes. In: Provan D, Gribben J (eds.). Molecular Hematology. 1st ed. pp. 75-84, Blackwell Science, New York, 1997
  7. Weiss DJ. Recognition and classification of dysmyelopoiesis in the dog: a review. J Vet Intern Med 2005, 19, 147-154 https://doi.org/10.1892/0891-6640(2005)19<147:RACODI>2.0.CO;2
  8. Weiss DJ. Evaluation of dysmyelopoiesis in cats: 34 cases (1996-2005). J Am Vet Med Assoc 2006, 228, 893-897 https://doi.org/10.2460/javma.228.6.893
  9. Weiss DJ, Aird B. Cytologic evaluation of primary and secondary myelodysplastic syndromes in the dog. Vet Clin Pathol 2001, 30, 67-75 https://doi.org/10.1111/j.1939-165X.2001.tb00261.x
  10. Werner LL, Gorman NT. Immune-mediated disorders of cats. Vet Clin North Am Small Anim Pract 1984, 14, 1039-1064 https://doi.org/10.1016/S0195-5616(84)50106-5
  11. Yu DH, Kim HW, Desai AR, Han IA, Li YH, Lee MJ, Kim IS, Chae JS, Park J. Molecular detection of feline hemoplasmas in feral cats in Korea. J Vet Med Sci 2007, 69, 1299-1301 https://doi.org/10.1292/jvms.69.1299
  12. Zini E, Hauser B, Meli ML, Glaus TM. Immunemediated erythroid and megakaryocytic aplasia in a cat. J Am Vet Med Assoc 2007, 230, 1024-1027 https://doi.org/10.2460/javma.230.7.1024