Korean Chemical Engineering Research

  • 제46권2호
  • /
  • Pages.217-221
  • /
  • 2008
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  • 0304-128X(pISSN)
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  • 2233-9558(eISSN)
한국화학공학회 (The Korean Institute of Chemical Engineers)
권호 표지

저주파수 초음파를 이용한 Lidocaine Gel의 피부투과 촉진 효과

Enhanced Transdermal Permeation Effects of Lidocaine Gel by Low Frequency Ultrasound

  • Jung, Dae-In (Department of Physical Therapy, Gwangju Health College) ;
  • Lee, Jung-Woo (Department of Physical Therapy, Kwangju Women's University) ;
  • Ahn, Hyo-Cho (College of Parmacy, Woosuk University) ;
  • Yang, Jae-Heon (College of Parmacy, Woosuk University) ;
  • Kim, Tae-Youl (Department of Physical Therapy, Dongshin University) ;
  • Cho, Seong-Wan (Department of Pharmaceutical Engineering, Konyang University) ;
  • Kim, Young-Il (Department of Pharmaceutical Engineering, Konyang University)
  • 투고 : 2008.01.23
  • 심사 : 2008.02.05
  • 발행 : 2008.04.30
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초록

다양한 초음파의 주파수와 강도 등의 물리적 인자에 대한 경피투과 촉진효과를 알아보기 위하여 lidocaine gel을 제조하고 hairless mouse의 피부를 이용하여 경피투과 촉진효과를 평가하였다. Lidocaine을 함유한 겔을 제조하여 안정성을 확인할 수 있었으며, 주파수에 따른 lidocaine의 경피투과량은 500 kHz 초음파의 경피투과량이 크게 증가하였으며, 특히 지속초음파에서 현저히 증가하였다. 초음파의 강도에 따른 lidocaine의 경피투과량은 강도가 높을수록 높게 나타났다. 500 kHz 초음파의 조사는 1 kHz에 비하여 flux를 유의성 있게 증가시켰으며, lag time을 상대적으로 지연되는 양상을 나타내었다. 따라서 현재 임상에서 가장 많이 사용하고 있는 1 kHz 초음파를 이용한 음파영동보다 500 kHz 초음파를 이용한 음파영동이 lidocaine의 투과량 증대를 위한 임상적 응용이 가능할 것으로 사료된다.

To investigate the enhancing effects in transdermal permeation of drug using newly designed ultrasound apparatus of 500 kHz, the transdermal permeation studies through the hairless mouse skin were conducted with lidocaine. The ultrasound apparatus of 500 kHz frequency and transducer were newly developed. The drug permeation studies were performed according to the ultrasound frequencies such as 1 MHz and 500 kHz at $1W/cm^2$ in intensity in continuous mode or pulsed mode, respectively. The results on transdermal permeation of lidocaine according to ultrasound intensity showed that the drug permeation increased as the intensity was higher.

키워드

참고문헌

  1. Tachibana, K. and Tachibana, S., "Transdermal Delivery Ofinsulin by Ultrasonic Vibration," J. Pharm., 43(4), 270-271(1991) https://doi.org/10.1111/j.2042-7158.1991.tb06681.x
  2. Zderic, V., Clark, J. I. and Martin, R. W., "Ultrasound-Enhanced Transcorneal Drug Delivery," Cornea Nov., 23(8), 804-11(2004) https://doi.org/10.1097/01.ico.0000134189.33549.cc
  3. Yang, J. H., Kim, D. K. and Kim, T. Y., "Anti-inflammatory Effects by Transdermal Application of Triamcinolone Acetonide Gel Using Phonophoresis in Rats," Int. J. Pharm., 302(1-2), 39-46 (2005) https://doi.org/10.1016/j.ijpharm.2005.06.011
  4. Ciccone, C. D., Leggin, B. G., Callamaro, J. J., "Effects of Ultrasound and Trolamine Salicylate Phonophoresis on Delayed-onset Muscle Soreness," Physical therapy, 71(9), 666-675(1991) https://doi.org/10.1093/ptj/71.9.666a
  5. Monti, D., Gianelli, R. and Chetoni, P., "Comparison of the Effect of Ultrasound and of Chemical Enhancers on Transdermal Permeation of Caffeine and Morphinethrough Hairless Mouse Skin In Vitro," Int. J. Pharm., 229(1-2), 131-137(2001) https://doi.org/10.1016/S0378-5173(01)00830-4
  6. Machet, L. and Boucaud, A., "Phonophoresis-Efficiency, Mech- Anisms and Skin Tolerance," Inter. J. Pharmc., 243(1-2), 1-15(2002) https://doi.org/10.1016/S0378-5173(02)00299-5
  7. Bommannan, D., Menon, G. K. and Okuyuma, H., "Sonophoresis 2. Examination of the Mechanism(s) of Ultrasound Enhanced Transdermal Drug Delivery," Pharm. Res., 9(8), 1043-1047(1992) https://doi.org/10.1023/A:1015806528336
  8. Zderic, V., Vaezy, S. and Martin, R. W., "Ocular Drug Delivery Using 2-kHz Ultrasound," Ultrasound Med. Biol., 28(6), 823-829(2002) https://doi.org/10.1016/S0301-5629(02)00515-X
  9. Patel, G. M., Chuang, A. Z. and Kiang, E., "Epithelial Healing Rates with Topical Ciprofloxacin, Ofloxacin, and Ofloxacin with Artificial Tears After Photorefractive Keratectomy," J. Cataract Refract Surg., 26(5), 690-694(2000) https://doi.org/10.1016/S0886-3350(00)00411-9
  10. Merino, G., Kalia, Y. N. and Guy, R. H., "Ultrasound-Enhanced Transdermal Transport," J. Pharmac. Sci., 92(6), 1125-37(2003) https://doi.org/10.1002/jps.10369
  11. Mitragotri, S. and Kost, J., "Low-Frequency Sonophoresis-a Review," Advanced Drug Delivery Reviews, 56(5), 589-601(2004) https://doi.org/10.1016/j.addr.2003.10.024
  12. Williams, A. R., "Phonophoresis-an in vivo Evaluation Using Three Topical Anaesthetic Preparations," Ultrasonics, 28(3), 137-140(1990) https://doi.org/10.1016/0041-624X(90)90075-Y
  13. Moussatov, A. G., Baker, A. C. and Duck, F. A., "A Possible Approach to the Treatment of Polycystic Ovarian Syndrome Using Focused Ultrasound," Ultrasonics, 36(8), 893-900(1998) https://doi.org/10.1016/S0041-624X(98)00008-0
  14. Gvarishvili, E. P. and Dushin, N. V., "Effect of Superphonoelectrophoresis on Chorioretinal Dystrophy," Vestn. Oftalmol., 115(4), 19-21(1999)
  15. Panova, I. G., Fateeva, V. I. and Petrishcheva, T. S., "A Pharmacokinetic Studyof Para-aminobenzoic Acid Administered into the Rabbit Eye by Phonophoresis," Izv. Akad. Nauk. Ser. Biol., Jul-Aug(4), 487-489(1995)
  16. Galinkin, J. L., Rose, J. B. and Harris, K., "Lidocaine Iontophoresis Versus Eutectic Mixture of Local Anesthetics (EMLA) for IV Placement in Children," Anesth. Analg., 94(6), 1484-1488 (2002) https://doi.org/10.1097/00000539-200206000-00020
  17. Wallace, M. S., Ridgeway, B. and Jun, E., "Topical Delivery of Lidocaine in Healthy Volunteers by Electroporation, Electroinc Orporation, or Iontophoresis-an Evaluation of Skin Anesthesia," Reg. Anesth. Pain. Med., 26(3), 229-38(2001)
  18. Becker, B. M. and Helfrich, S., "Ultrasound with Topical Anesthetic Rapidly Decreases," Pain of Intravenous Cannulation. Acad. Emerg. Med., 12(4), 276-293(2005)
  19. Asano, J., Suisha, F. and Takada, M., "Effect of Pulsed Output Ultrasound on the Transdermal Absorption of Indomethacin From an Ointment in Rats," Biol. Pharm. Bull., 20(3), 288-291(1997) https://doi.org/10.1248/bpb.20.288
  20. McElnay, J. C., Matthews, M. P. and Harland, R., "The Effect of Ultrasound on the Percutaneous Absorption of Lignocaine," Br. J. Clin. Pharmacol,, 20(4), 421-424(1985) https://doi.org/10.1111/j.1365-2125.1985.tb05089.x
  21. Burry, K. A., Patton, P. E. and Hermsmayer, K., "Percutaneous Absorption of Progesteronein Postmenopausal Women Treated with Transdermal Estrogen," Am. J. Obstet. Gyneco., 180(6 Pt 1), 1504-1511(1999) https://doi.org/10.1016/S0002-9378(99)70046-3
  22. Katz, N. P., Shapiro, D. E. and Herrmann, T. E., "Rapid onset of Cutaneous Anesthesia with EMLA Cream After Pretreatment with a New Ultrasound-Emitting Device," Anesth. Analg., 98(2), 371-6(2004)
  23. Kim, M.-J., Kim, Y.-I. and Yang, J.-H., "Formulation Design for Skin Permeation of Lincomycin Cream," Yakhak Hoeji, 47(3), 154-158 (2003)
  24. Lenart, I. and Auslander, D., "The Effect of Ultrasound Ondiffusion Through Membranes," Ultrasonics, 18(5), 216-218(1980) https://doi.org/10.1016/0041-624X(80)90123-7
  25. Tezel, A., Sens, A. and Mitragotri, S., "Investigations of the Role of Cavitation in Low-Frequency Sonophoresis Using Acoustic Spectroscopy," J. Pharm. Sci., 91, 444-453(2002) https://doi.org/10.1002/jps.10024
  26. Meidan, V. M., Docker, M. F. and Walmsley, A. D., "Low Intensity Ultrasound as a Probe to Elucidate Therelative Follicular Contribution to Total Transdermal Absorption," Pharm. Res., 15(1), 85-92(1998) https://doi.org/10.1023/A:1011956905388
  27. Tang, H., Blankschtein, D. and Langer, R., "An Investigation of the Role of Cavitation in Low-Frequency Ultrasound-Mediated Transdermal Drug Transport," Pharm. Res., 19(8), 1160-1169(2002) https://doi.org/10.1023/A:1019898109793
  28. Fang, J. Y., Fang, C. L. and Sung, K. C., "Effect of Low Frequency Ultrasound on the in vitro Percutaneous Absorption of Clobetasol 17-Propionate," J. Pharm., 191(1), 3342(1999)
  29. Kozanoglu, E., Basaran, S. and Guzel, R., "Short Term Efficacy of Ibuprofen Phonophoresis Versus Continuous Ultrasound Therapy in Knee Osteoarthritis," Swiss Med. Wkly., 133(23-24), 333-338 (2003)