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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Wnt signaling in cartilage development and degeneration

  • Chun, Jang-Soo (Cell Dynamics Research Center, Department of Life Science, Gwangju Institute of Science and Technology) ;
  • Oh, Hwan-Hee (Cell Dynamics Research Center, Department of Life Science, Gwangju Institute of Science and Technology) ;
  • Yang, Si-Young (Cell Dynamics Research Center, Department of Life Science, Gwangju Institute of Science and Technology) ;
  • Park, Mee-Young (Cell Dynamics Research Center, Department of Life Science, Gwangju Institute of Science and Technology)
  • Published : 2008.07.31
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Abstract

The Wnt signaling network, which is composed of Wnt ligands, receptors, antagonists, and intracellular signaling molecules, has emerged as a powerful regulator of cell fate, proliferation, and function in multicellular organisms. Over the past two decades, the critical role of Wnt signaling in embryonic cartilage and bone development has been well established, and much has been learnt regarding the role of Wnt signaling in chondrogenesis and cartilage development. However, relatively little is known about the role of Wnt signaling in adult articular cartilage and degenerative cartilage tissue. This review will briefly summarize recent advances in Wnt regulation of chondrogenesis and hypertrophic maturation of chondrocytes, and review data concerning the role of Wnt signaling in the maintenance and degeneration of articular chondrocytes and cartilage.

Keywords

References

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