Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Antimicrobial Activities of Sophorolipids and Its Application for Cosmetics

Sophorolipid의 항균효과와 화장품에의 응용

  • Cho, Wan-Goo (College of Alternative Medicine, Jeonju University) ;
  • Park, Hyo-Soon (College of Education, Chonbuk National University, Korea) ;
  • Ahn, Byoung-Joon (College of Education, Chonbuk National University, Korea)
  • 조완구 (전주대학교 대체의학대학 대체건강관리학부) ;
  • 박효순 (전북대학교 사범대학 과학교육학부) ;
  • 안병준 (전북대학교 사범대학 과학교육학부)
  • Published : 2008.12.30
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Abstract

Some surfactants known as biosurfactants, are produced biologically by yeast and bacteria from various substances. They are more effective and environmentally friendly than many other synthetic surfactants. Antimicrobial activities of sophorolipids produced by Candida bombiocola were investigated against various microorganisms. Minimal Inhibitory concentration (MIC) of sophorolipid against S. mutans, C. xerosis, and P. acnes were 0.005, 0.05, and 0.005%, respectively. The antimicrobiological activities were more effective than those of SLS and APG. Skin exfoliating and moisturizing effects of vehicles with the sophorolipids were tested. The skin turnover time of aqueous solution with 0.25% sophorolipids was similar to that of aqueous solution with 5.0% lactic acid. Higher moisturizing effects on skin showed as the concentration of sophorolipids increased. We suggest that the sophorolipids can be used for cosmetics as an antimicrobiological agent and an active materials of skin moisturizing and exfoliating.

바이오계면활성제는 생물학적으로 박테리아나 효모 등에 의해 많은 기질로 부터 생산된다. 바이오계면활성제는 많은 다른 합성 계면활성제에 비해서 환경친화적이고 보다 효과적인 것으로 알려져 있다. 본 연구에서는 Candida bombiocola로부터 생성된 소포로리피드의 항균효과를 다양한 균에 대해서 시험하였다. 소포로리피드의 치아우식 원인균(S. mutans), 액취균(C. xerosis) 및 여드름균(P. acnes)에 대한 최소억제농도(MIC)는 각각 0.005, 0.05, 0.005% (w/v)이였다. 이러한 항균효과는 합성 계면활성제인 SLS나 APG에 비해 우수한 항균효과를 보였다. 소포로리피드를 함유한 제형에서의 각질박리와 보습 효과를 측정하였다. 0.25% 수용액의 소포로리피드는 5.0% 젖산 수용액과 동등한 수준의 각질박리효과를 보였으며 보습효과는 소포로리피드를 함유한 에멀젼 제형에서 농도 의존적인 경향을 보였다. 이러한 결과는 소포로리피드을 항균제나 보습 또는 각질박리제로서 화장품에 대한 사용 가능성을 제시한다.

Keywords

References

  1. B. P. Binks, W. G. Cho, P. D. I. Fletcher, and D. N. Petsev, Stability of oil-in-water emulsions in a low interfacial tension system, Langmuir, 16, 1025 (2000) https://doi.org/10.1021/la990952m
  2. W. K. Kim and E. K. Kim, Application of biosurfactant (sophorolipid) produced from Candida bombiocola, Korean Biotechnol. Bioeng., 7(2), 107 (1992)
  3. K. J. Cho, Y. B. Kim, and E. K. Kim, Production and application of sophorolipid, a microbial surfactant, Korean Biotechnol. Bioeng., 14(6), 747 (1999)
  4. L. Zhang, P. Somasundaran, S. K. Singh, A. P. Felse, and R. Gross, Synthesis and interfacial properties of sophorolipid derivatives, Colloids and Surfaces A: Physicochem. Eng. Aspects., 240, 75 (2004) https://doi.org/10.1016/j.colsurfa.2004.02.016
  5. S. Maneerat, Production of biosurfactants using substrates from renewable-resources, Songklanakarin, J. Sci. Technol., 27(3), 675 (2005)
  6. K. Muthusamy, S. Gopalakrishnan, T. K. Ravi, and P. Sivachidambaram, Biosurfactants: properties, commercial production and application, Current Science, 94(6), 736 (2008)
  7. J. D. Desai and I. M. Banat, Microbial production of surfactants and their commercial potential, Microbilogy & Molecular Biology Reviews, 61(1), 47 (1997)
  8. S. C. Lin, Biosurfactant: recent advances, J. Chem. Tech. Biotechnol., 66, 109 (1996) https://doi.org/10.1002/(SICI)1097-4660(199606)66:2<109::AID-JCTB477>3.0.CO;2-2
  9. P. Dykes, Surfactants and the skin, Int. J. Cosmetic Sci., 20, 53 (1998) https://doi.org/10.1046/j.1467-2494.1998.171735.x
  10. S. H. Kang, K. J. Cho, C. S. Han, and E. K. Kim, Effects of microbial surfactants on bioremediation, Theor. Appl. of Chem. Eng., 42(2), 2945 (1998)
  11. Y. Zhang and R. M. Miller, Effect of rhamnolipid (biosurfactant) structure on solubilization and biodegradation of n-alkanes, Applied and Environmental Microbiology, 61(6), 2247 (1995)
  12. W. C. Lin, S. T. Lin, and S. L. Shu, Comparison of analyses of surfactants in cosmetics using high-performance liquid chromatography and high-performance capillary electrophoresis, J. Surfactants and Detergents, 3(1), 67 (2000) https://doi.org/10.1007/s11743-000-0115-2
  13. T. J. Hall Manning, G H. Holland, G. Rennie, P. Revell, J. Hines, M. D. Barratt, and D. A. Basketter, Skin irritation potential of mixed surfactant systems, Food Chem. Toxicol., 36(3), 233 (1998) https://doi.org/10.1016/S0278-6915(97)00144-0
  14. J. W. Kim, I. S. Chang, and H. H. Kang, Application of polymers in the field of functional cosmetics, Polymer Science & Technology, 13(4), 423 (2002)
  15. M. Attasa, T. Posthumusa, B. Schattkaa, M. Sowaa, H. Mantscha, and S. Zhang, Long-wavelength near-infrared spectroscopic imaging for in vivo skin hydration measurements, Vibrational Spectroscopy, 28, 37 (2002) https://doi.org/10.1016/S0924-2031(01)00143-6
  16. K. P. Wilhelm, G. Freitag, and H. H. Wolff, Surfactant-induced skin irritation and skin repair. Evaluation of the acute human irritation model by noninvasive techniques, J. Am. Acad. Dermatol., 30(6), 944 (1994) https://doi.org/10.1016/S0190-9622(94)70114-8