Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Antinociceptive activity of the ethanolic extract of Ficus racemosa Lin. (Moraceae)

  • Ferdous, Muhshina (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University) ;
  • Rouf, Razina (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University) ;
  • Shilpi, Jamil Ahmad (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University) ;
  • Uddin, Shaikh Jamal (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University)
  • Published : 2008.03.31
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Abstract

The ethanolic extract of Ficus racemosa Lin. (Moraceae) bark and fruit were tested for its possible antinociceptive activity study on acetic acid induced writhing method in mice. Both the bark and fruit extracts at a dose of 500 mg/kg body weight showed significant antinociceptive activity on the experimental animals. The fruit extract showed most potent inhibition of acetic acid induced writhing in mice (61.38%, P < 0.001) where as the bark extract showed inhibition only 42.6% (P < 0.001) and all the result were statistically significant.

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References

  1. Bhaskara RR, Murugesan T, Pal M, Saha BP, Mandal SC. (2003) Antitussive potential of methanol extract of stem bark of Ficus racemosa L. Phytother. Res. 17, 1117-1118 https://doi.org/10.1002/ptr.1325
  2. Ghani A. (1998) Medicinal Plants of Bangladesh. Asiatic Society of Bangladesh, Dhaka
  3. Li RW, Leach DN, Myers SP, Lin GJ, Waterman PG. (2004) A new anti-inflamatory glucoside from Ficus racemosa L. Planta Med. 421-6
  4. Mandal SC, Maity TK, Das J, Pal M, Saba BP. (1999) Hepatoprotective activity of Ficus racemosa L. leaf extract. Phytother. Res. 13, 430-432
  5. Mukherjee PK, Saha K, Murugesan T, Mandal SC, Das J, Pal M, Saba BP. (1998) Screening of antidirrhoeal profile of some plant extracts of a specific region of West Bengal. J. Ethnopharmacol. 13, 430-432
  6. Mary JM, Richard AH, Pamela CC. (1997) Lippincott's Illustrated Reviews of Pharmacology, $2^{nd}$ edition, Lippincott-Raven Publishers, Philadelphia, USA
  7. Parke DV, Sapota A. (1996) Chemical toxicity and reactive species. Int. J. Occup. Med. Environ. Health 9, 119-123
  8. Rao RB, Anupama K, Swaroop KR, Murugesan T, Pal M, Saha BP, Mandal SC. (2002) Evaluation of antipyretic potential of Ficus racemosa bark. Phytomedicine 9, 731-733 https://doi.org/10.1078/094471102321621340
  9. Ratnasooriya WD, Jayakody JR, Nadarajah T. (2003) Antidiuretic activitity of aqueous bark extract of Sri Lankan Ficus racemosa in rats. Acta Biol. Hung. 54, 357-363 https://doi.org/10.1556/ABiol.54.2003.3-4.13
  10. Rang HP, Dale MM. (1993) Pharmacology, pp. 706-711, $2^{nd}$ edition, Churchill Livingstone publisher, UK.
  11. Shilpi SJ, Uddin SJ, Rouf R, Billah MM. (2004) Central nervous system depressant activity of Diospyros peregrina bark, Orient. Pharm. Exp. Med. 4, 249-252
  12. Uddin SJ, Shilpi JA, Alam SMS, Alamgir M, Rahman MT, Sarker SD. (2005) Antidiarrhoeal activity of the methanol extract of the barks of Xylocarpus molucensis in castor oil and magnesium sulphate-induced diarrhoea models in mice. J. Ethnopharmacol. 101, 139-143 https://doi.org/10.1016/j.jep.2005.04.006
  13. Uddin SJ, Shilpi JA, Barua J, Rouf R. (2005) Antinociceptive activity of Ceriops decandra leaf and pneumatophore. Fitoterapia 76, 261-263 https://doi.org/10.1016/j.fitote.2004.12.015
  14. Uddin SJ, Shilpi JA, Rouf R, Ferdous MM, Nahar L, Sarker SD. (2006) Antinociceptice activity of some medicinal plants. Orient. Pharm. Exp. Med. 6, 96-101
  15. Winrow VR, Winyard PG, Morris CT, Black DR. (1993) Free radicals in inflammation: Second messengers and mediators of tissue destruction. Br. Med. Bull. 49, 506-540
  16. Yusuf M, Chowdhury JU, Wahab MA, Begum J. (1994) Medicinal Plants of Bangladesh, Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh

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