Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Onion Kimchi Extract Supplementation on Blood Glucose and Serum Lipid Contents in Streptozotocin-induced Diabetic Rats

양파김치 추출물 투여가 Streptozotocin 유발 당뇨병 흰쥐의 혈당강하 및 혈중지질 함량에 미치는 영향

  • Yang, Ya-Ru (Dept. of Food Engineering and Regional Food Industrial Innovation Center (RIC), Mokpo National University) ;
  • Kim, Hag-Lyeol (Dept. of Food Engineering and Solar Salt and Halophyte R&D Center (SSHC), Mokpo National University) ;
  • Park, Yang-Kyun (Dept. of Food Engineering and Regional Food Industrial Innovation Center (RIC), Mokpo National University)
  • 양아여 (목포대학교 식품공학과, 식품산업지역혁신센터) ;
  • 김학렬 (목포대학교 식품공학과, 천일염 및 염생식물산업화사업단) ;
  • 박양균 (목포대학교 식품공학과, 식품산업지역혁신센터)
  • Published : 2008.04.30
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Abstract

The purpose of this study was carried out to examine the effects of onion kimchi extract supplementation on blood glucose level and serum lipid components in streptozotocin (STZ)-induced diabetic rats for 4 weeks. STZ was administered as a single dose (50 mg/kg BW) to induce diabetes, and the diabetic rats were divided into eight groups (normal, diabetic control, and six treatment groups). The dose of onion kimchi extract 100 (OK-100), 200 (OK-200), and 400 (OK-400) mg/kg/day or quercetin as a main compound of onion 5 (Q-5), 10 (Q-10), and 20 (Q-20) mg/kg/day were orally administered daily to STZ-induced diabetic rats for 4 weeks after STZ injection. The diabetic control rats (465.6 mg/dL) showed significantly higher blood glucose level than the normal rats (76.3 mg/dL) after 4 weeks, but was significantly reduced with onion kimchi extract and quercetin supplementation (p<0.001). Changes in body weight, kidney weight and urine volume were not significantly different in diabetic control rats, and in onion kimchi extract and quercetin treated rats. The serum total cholesterol levels of control were significantly decreased in onion kimchi extract and quercetin supplementation groups, respectively (p<0.001). The blood urea nitrogen level and urinary protein excretion in diabetic rats were not significant different among the groups. These results suggest that onion kimchi extract supplementation in STZ-induced diabetic rats may be a very important factor for the reduction of blood glucose and serum cholesterol profiles.

양파김치를 이용한 가공식품의 개발을 위해 streptozotocin(STZ)으로 유도한 당뇨병 흰쥐를 이용하여 양파김치 추출물 투여에 대한 혈당강하 및 지질성분의 함량 변화를 조사하였다. 체중변화는 정상군은 4주 사육기간 동안 지속적으로 증가하였으나, STZ 유도 당뇨대조군은 유의하게 감소되었다. 양파김치 추출물과 quercetin 투여군에서도 유의한 체중감소가 있었으나 투여군 간에 유의한 차이는 없었다. 혈당 농도는 정상군에 비해 STZ로 유도한 당뇨흰쥐에서 유의하게 증가되었으며, 투여 2주에서부터 대조군에 비해 양파김치 추출물 투여군과 quercetin 투여군에서 유의하게 감소되었다. 그러나 식이농도 증가 및 투여군 간에 유의한 차이는 없었다. 소변량은 정상군에 비해 STZ로 유도한 당뇨흰쥐에서 유의하게 증가되었으나 양파김치 추출물 및 quercetin 투여군의 식이농도 증가에 유의한 차이는 없었다. 신장무게는 정상쥐에 비해 당뇨쥐에서 증대되었으며, 양파김치 추출물 및 quercetin 투여군에서 유의하게 낮은 수준을 나타내어 정상군과 차이가 없었다. 혈청 총콜레스테롤 및 중성지질은 정상쥐에 비해 STZ 유도 당뇨대조군에서 증가되었으나 양파김치 추출물 및 quercetin 투여군에서 낮은 수준을 나타내었다. 이러한 결과는 양파김치 추출물 섭취가 당뇨쥐에서 증가된 혈당 및 혈청 콜레스테롤 수준을 감소시킬 수 있음을 의미하는 것이다.

Keywords

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