KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Development of Bioartificial Skin for Skin Regeneration

손상된 피부 재건을 위한 바이오인공피부의 개발 동향

  • Seo, Young-Kwon (Dongguk University Research Institute of Biotechnology, Dongguk University) ;
  • Song, Kye-Yong (Department of Pathology, Chung-Ang University) ;
  • Park, Jung-Keug (Department of Chemical and Biochemical Engineering, Dongguk University)
  • 서영권 (동국대학교 생명과학연구원) ;
  • 송계용 (중앙대학교 의과대학 병리학교실) ;
  • 박정극 (동국대학교 생명화학공학과)
  • Published : 2008.02.29
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Abstract

There are many different approaches to healing of acute and chronic ulcer and large skin defect, such as burn. Currently available wound covers fall into two categories. Permanent covering, such as autografts, and temporary ones, such as allograft including de-epidermized cadaver skin, bioartificial skin, xenografts, and synthetic dressings. Autologous skin grafting in the form of split- or full-thickness skin is still the good standard. Following on from developments in the 1980s involving the use of cultured keratinocyte grafts in wound healing, the last decade has been great progress in the fabrication of composite bioartificial skin grafts. However, two bottleneck on producing cultured bioartificial skin, whether of the simple epithelial cell sheet type, or the more complex composite type, continue to be the generation of sufficient keratinocytes cheaply and quickly and develop biocompatible dermal scaffolds. This article covers the development, clinical application, and current research directions associated with bioartificial skin.

Keywords

References

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