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The anti-hypertensive effect of ginseng in patients with mild hypertension

  • Kim, Young-Suk (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Jung, Woo-Sang (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Seong-Uk (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Moon, Sang-Kwan (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Jung-Mi (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Ko, Chang-Nam (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Cho, Ki-Ho (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung-Hee University) ;
  • Bae, Hyung-Sup (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung-Hee University)
  • Published : 2008.02.29

Abstract

Ginseng has been traditionally used to recover vital energy from Qi deficiency in oriental countries. Recent reports suggested that ginseng could regulate blood pressure (BP), but much controversy still remain. Therefore, we intended to assess the anti-hypertensive effect of some ginseng species on Koreans and Chinese. This is a randomized, double blinded controlled clinical trial. The study subjects were recruited from the mild hypertensive patients who belonged prehypertension(120/80 to 139/89 mmHg) and stage I hypertension (140/90 to 159/99 mmHg) in Korea and China. After assigning the subjects into a Korean, a Chinese, and an American ginseng group by randomization, we prescribed ginseng with the dose of 4.5 g per a day for 4 w. To assess the anti-hypertensive effect, we compared the mean of systolic and diastolic BP between before and after ginseng medication by 24 h Ambulatory Blood Pressure Monitor (24 h ABPM). We also monitored adverse effect and laboratory findings to secure the subjects' safety. There were 64 subjects treated with Korean ginseng, 58 treated with Chinese ginseng, and 64 treated with American ginseng. All of the ginseng species reduced subjects' BP. Especially, Korean and Chinese ginseng showed more excellent effects. The secondary analysis on the subjects' nationality revealed that all of the ginseng species showed more significant anti-hypertensive effect in Chinese than in Koreans. We suggest ginseng could be useful for mild hypertension regardless of its species. And it would be safe within the dosage of 4.5 g per a day.

Keywords

References

  1. Belogortseva NI, Yoon JY, Kim KH. (2000) Inhibition of Helicobacter pylori hemagglutination by polysaccharide fractions from roots of Panax ginseng. Planta Med. 66, 217-220 https://doi.org/10.1055/s-2000-8658
  2. Chang YS, Seo EK, Gyllenhaal C, Block KI. (2003) Panax ginseng: a role in cancer therapy? Integr. Cancer Ther. 2, 13-33 https://doi.org/10.1177/1534735403251167
  3. Coleman CI, Hebert JH, Reddy P. (2003) The effects of Panax ginseng on quality of life. J. Clin. Pharm. Ther. 28, 5-15 https://doi.org/10.1046/j.1365-2710.2003.00467.x
  4. Ellis JM, Reddy P. (2002) Effects of Panax ginseng on quality of life. Ann Pharmacother. 36, 375-379 https://doi.org/10.1345/aph.1A245
  5. Feng PF, Qin NP, Qiao Q. (1997) Clinical and experimental study of improving left ventricular diastolic function by total saponins of panax notoginseng. Zhongguo Zhong Xi Yi Jie He Za Zhi 17, 714-717
  6. Ferrando A, Vila L, Voces JA, Cabral, AC Alvarez AI, Prieto JG. (1999) Effects of a standardized Panax ginseng extract on the skeletal muscle of the rat: a comparative study in animals at rest and under exercise. Planta Med. 65, 239-244 https://doi.org/10.1055/s-1999-14081
  7. Friedl R, Moeslinger T, Kopp B, Spieckermann PG. (2001) Stimulation of nitric oxide synthesis by the aqueous extract of Panax ginseng root in RAW 264.7 cells. Br. J. Pharmacol. 134, 1663-1670 https://doi.org/10.1038/sj.bjp.0704425
  8. Han KH, Choe SC, Kim HS, Sohn DW, Nam KY, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW. (1998) Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am. J. Chin. Med. 26,199-209 https://doi.org/10.1142/S0192415X98000257
  9. Helms S. (2004) Cancer prevention and therapeutics: Panax ginseng. Altern. Med. Rev. 9, 259-274
  10. Huang YC, Chen CT, Chen SC, Lai PH, Liang HC, Chang Y, Yu LC, Sung HW. (2005) A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration. Pharm. Res. 22, 636-646 https://doi.org/10.1007/s11095-005-2500-3
  11. Hwang SY, Kim WJ, Wee JJ, Choi JS, Kim SK. (2004) Panax ginsengimproves survival and sperm quality in guinea pigs exposed to 2,3,7,8-tetrachlorodibenzo - p-dioxin. BJU Int. 94, 663-668 https://doi.org/10.1111/j.1464-410X.2004.05019.x
  12. Jeon BH, Kim CS, Park KS, Lee JW, Park JB, Kim KJ, Kim SH, Chang SJ, Nam KY. (2000) Effect of Korea red ginseng on the blood pressure in conscious hypertensive rats. Gen. Pharmacol. 35, 135-141 https://doi.org/10.1016/S0306-3623(01)00096-9
  13. Jeong CS. (2002) Effect of butanol fraction of Panax ginseng head on gastric lesion and ulcer. Arch. Pharm. Res. 25, 61-66
  14. Jeong GT, Park DH, Ryu HW, Hwang B, Woo JC, Kim D, Kim SW. (2005) Production of antioxidant compounds by culture of Panax ginseng C.A. Meyer hairy roots: I. Enhanced production of secondary metabolite in hairy root cultures by elicitation. Appl. Biochem. Biotechnol. 121-124, 1147-1157 https://doi.org/10.1385/ABAB:124:1-3:1147
  15. Jin XQ, Duan SF, Niu RJ. (1995) Effect of shen mai injection and its combinations on blood gas and hemodynamics of rats exposed to chronic hypoxia. Zhongguo Zhong Xi Yi Jie He Za Zhi 15, 162-164
  16. Jung CH, Seog HM, Choi IW, Choi HD, Cho HY. (2005) Effects of wild ginseng (Panax ginseng CA Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats. J. Ethnopharmacol. 98, 245-250 https://doi.org/10.1016/j.jep.2004.12.030
  17. Kennedy DO, Haskell CF, Wesnes KA, Scholey AB. (2004) Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol. Biochem. Behav. 79, 401-411 https://doi.org/10.1016/j.pbb.2004.07.014
  18. Kim JY, Germolec DR, Luster MI. (1990) Panax ginseng as a potential immunomodulator: studies in mice. Immunopharmacol. Immunotoxicol. 12, 257-276 https://doi.org/10.3109/08923979009019672
  19. Kuo SC, Teng CM, Lee JC, Ko FN, Chen SC, Wu TS. (1990) Antiplatelet components in Panax ginseng. Planta Med. 56, 164-167 https://doi.org/10.1055/s-2006-960916
  20. Langhansova L, Konradova H, Vanek T. (2004) Polyethylene glycol and abscisic acid improve maturation and regeneration of Panax ginseng somatic embryos. Plant Cell Rep. 22, 725-730 https://doi.org/10.1007/s00299-003-0750-2
  21. Lim TS, Na K, Choi EM, Chung JY, Hwang JK. (2004) Immunomodulating activities of polysaccharides isolated from Panax ginseng. J. Med. Food 7, 1-6 https://doi.org/10.1089/109662004322984626
  22. Park HJ, Rhee MH, Park KM, Nam KY, Park KH. (1995) Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane $A_2$ in human platelet aggregation. J. Ethnopharmacol. 49, 157-162 https://doi.org/10.1016/0378-8741(95)01317-2
  23. Rai D, Bhatia G, Sen T, Palit G. (2003) Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study. J. Pharmacol. Sci. 93, 458-464 https://doi.org/10.1254/jphs.93.458
  24. Salvati G, Genovesi G, Marcellini L, Paolini P, De Nuccio I, Pepe M, Re M. (1996) Effects of Panax Ginseng C.A. Meyer saponins on male fertility. Panminerva Med. 38, 249-254
  25. Seo JC, Huh JG, Han SW, Lee KY, Byun JS, Kim MS, Hah ID, Yim KH. (2003) The effects of Korean ginseng and American ginseng on body temperature in Koreans and Chinese. Orient. Physiol. Pathol. 17, 837-841
  26. Seo JC, Lee SY, Lee KM, Yim SC, Jung TY, Ahn HD, Han SW, Hah ID, Huh JG, Lee KY, Kim MS. (2004) The effects of Korean ginseng and American ginseng on blood pressure and pulse rate in Koreans and Chinese. Orient. Physiol. Pathol. 18, 606-611
  27. Seol YK, Kim JW. (2002) A Comparative Study on the Characteristics According to the Sasang Constitution. J. Sasang Constitutional Med. 14, 45-57
  28. Shin JY, Song JY, Yun YS, Yang HO, Rhee DK, Pyo S. (2002) Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function. Immunopharmacol. Immunotoxicol. 24, 469-482 https://doi.org/10.1081/IPH-120014730
  29. Sohn J, Lee CH, Chung DJ, Park SH, Kim I, Hwang WI. (1998) Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells. Exp. Mol. Med. 30, 47-51
  30. Song IB, Park KS. (2002) Sasang Constitutional Medicine and Incurable Disease. J. Sasang Constitutional Med. 14, 1-6
  31. Sung J, Han KH, Zo JH, Park HJ, Kim CH, Oh BH. (2000) Effects of red ginseng upon vascular endothelial function in patients with essential hypertension. Am. J. Chin. Med. 28, 205-216 https://doi.org/10.1142/S0192415X00000258
  32. Watanabe H, Ohta H, Imamura L, Asakura W, Matoba Y, Matsumoto K. (1991) Effect of Panax ginseng on age-related changes in the spontaneous motor activity and dopaminergic nervous system in the rat. Jpn. J. Pharmacol. 55, 51-56 https://doi.org/10.1254/jjp.55.51
  33. Wesnes KA, Faleni RA, Hefting NR, Hoogsteen G, Houben JJ, Jenkins E, Jonkman JH, Leonard J, Petrini O, van Lier JJ. (1997) The cognitive, subjective, and physical effects of a ginkgo biloba/panax ginseng combination in healthy volunteers with neurasthenic complaints. Psychopharmacol. Bull. 33, 677-683
  34. Yoshizato H, Fujikawa T, Shibata M, Tanaka M, Nakashima K. (1999) Stimulation of growth hormone gene expression in the pituitary and brain by Panax ginseng C. A. MEYER. Endocr. J. 46 Suppl, S85-88 https://doi.org/10.1507/endocrj.46.Suppl_S85