BEHCET DISEASE WITH SUPERIOR VENA CAVA THROMBUS IN A PATIENT PRESENTING DELAYED FACIAL WOUND HEALING : A CASE REPORT

단순안면열상환자에서 발생한 창상치유지연 및 상대정맥혈전증을 동반한 베체트병 : 증례보고

  • Choi, Sun-Mi (Department of Oral & Maxillofacial Surgery, Hankook General Hospital) ;
  • Ha, Joo-Hyo (Department of Oral & Maxillofacial Surgery, Hankook General Hospital) ;
  • Kim, Sun-Ae (Department of Oral & Maxillofacial Surgery, Hankook General Hospital) ;
  • Choi, Mi-Ra (Department of Oral & Maxillofacial Surgery, Hankook General Hospital) ;
  • Jung, Su-Jin (Department of Oral & Maxillofacial Surgery, Hankook General Hospital) ;
  • Lee, Hyen-Soo (Department of Oral & Maxillofacial Surgery, Hankook General Hospital) ;
  • Yang, Soo-Nam (Department of Oral & Maxillofacial Surgery, Hankook General Hospital)
  • 최선미 (청주한국병원 구강악안면외과) ;
  • 하주효 (청주한국병원 구강악안면외과) ;
  • 김선애 (청주한국병원 구강악안면외과) ;
  • 최미라 (청주한국병원 구강악안면외과) ;
  • 정수진 (청주한국병원 구강악안면외과) ;
  • 이현수 (청주한국병원 구강악안면외과) ;
  • 양수남 (청주한국병원 구강악안면외과)
  • Published : 2008.03.31

Abstract

Behcet Disease is a multisystem inflammatory disorder of unknown orign. It is characterized by recurrent oral ulcer, genital ulcer, skin lesions and ocular inflammation, and which may involve the joints, skin, central nervous system and gastrointestinal tract. Because Behcet Disease dose not have any specific symptoms and laboratory findings, the diagnosis is made on the basis of the criteria proposed by the the International Study Group for Behcet Disease. Behcet Disease is affecting both arteries and veins, and clinically manifest large vessel involvement occurs in between 7 and 49% of patients. Superior vena cava thrombosis is a rare but well-recognized manifestation of Behcet disease. We report a case of a Behcet Disease with superior vena cava thrombosis in a patient presenting delayed facial wound healing.

Keywords

References

  1. Behcet H : Uber rezidivierende aphthose, durch ein Virus verursachte Geschwure am Mund, am Auge und an den Genitalien. Derm Wochenschr 36 : 1152, 1937
  2. Michelson TB, Chisri FV : Behcet's disease. Surv Ophthalmol 26 : 190, 1982 https://doi.org/10.1016/0039-6257(82)90079-0
  3. Oshima Y, Shimizu T, Yolohari R et al : Clinical studies on Behcet's syndrome. Ann Rheum Dis 22 : 36, 1963 https://doi.org/10.1136/ard.22.1.36
  4. Shimizu T, Ehrlich GE, Inaba G et al : Behcet's disease. Semin Arthritis Rheum 8 : 223, 1979. https://doi.org/10.1016/0049-0172(79)90004-0
  5. Feigenbaum A : Description of Behcet's syndrome in the Hippocratic third book of endemic disease. Br J Ophthalmol 40 : 355, 1956 https://doi.org/10.1136/bjo.40.6.355
  6. Verity DH, Marr JE, Ohno S et al : Behcet's disease, the Silk Road and HLA-B51: histological and geographical perspectives. Tissue Antigens 54 : 213, 1999 https://doi.org/10.1034/j.1399-0039.1999.540301.x
  7. Serdarglu P, Yazici H, Ozdemir C et al : Neurologic involvement in Behcet's syndrome. A prospective study. Arch Neurol 46 : 265, 1989 https://doi.org/10.1001/archneur.1989.00520390031011
  8. Sagdic K, Ozer G, Saba D et al : Venous Lesions in Behcet's disease. Eur J Endovasc Surg 11 : 437, 1996 https://doi.org/10.1016/S1078-5884(96)80178-X
  9. Koc Y, Gullu I, Akpek G et al : Vascular involvement in Behcet's disease. J Rheumatol 19 : 402, 1992
  10. Kuzu MA, Ozaslan C, Koksoy C et al : Vascular involvement in Behcet's disease: 8-year audit. World J Surg 18 : 948, 1994 https://doi.org/10.1007/BF00299119
  11. Gurler A, Boyvat A, Tursen U : Clinical manifestations of Behcet's disease: an analysis of 2147 patients. Yonsei Med J 38 : 423, 1997 https://doi.org/10.3349/ymj.1997.38.6.423
  12. Kabbaj N, Benjelloum G, Gueddari FZ et al : Vascular involvement in Behcet's disease. Based on 40 patient records. J Radiol 74 : 649, 1993
  13. Lorizzo JL : Behcet's disease. Arch Dermatol 122 : 556, 1986 https://doi.org/10.1001/archderm.122.5.556
  14. Sung-Woo Han, Young-Mo Kang, Young-Wook Kim et al :Vascular involvement in Behcet disease. J Korea Internal Medicine 64 : 542, 2003
  15. Hizli N, Sahin G, Sahin F : Plasma prostacycline levels in Behcet's disease. Lancet 1 : 1454, 1985
  16. Guermazi S, Hamza M, Dellagi K : Protein C deficiency and antibodies to protein S in patients with Behcet's disease. Thromb Res 86 : 197, 1997 https://doi.org/10.1016/S0049-3848(97)00063-7
  17. Comp P C, Nixon R R, Cooper M R et al : Familial protein S deficiency is associated with recurrent thrombosis. J Clin Invest 74 : 2082, 1984 https://doi.org/10.1172/JCI111632
  18. Engesser L, Broekmans AW, Briet E et al : Hereditary protein S deficiency. Clinical manifestation. Ann Intern Med 106 : 239, 1987
  19. International Study Group for Behcet's disease: Evaluation of diagnostic criteria in Behcet's diseasetowards internationally agreed criteria. Br J Rheumatol 31 : 299, 1992 https://doi.org/10.1093/rheumatology/31.5.299
  20. Mizushima Y : Recent research into Behcet's disease in Japan. Int J Tissue React 10 : 59, 1988
  21. Yazici H, Yurdakul S, Hamuryudan V : Behcet's syndrome. In Rheumatology 7 : 26, 1998
  22. Blobner F : Zur rezidivierenden hypopyon-iritis. Zeitschrift Augenheik 91 : 129, 1937
  23. Lee S : Chair's Summary : Behcet's disease. Paper presented at The 18th World Congress of Dermatology. New York, Parthenon Publishing Company. 1073, 1992
  24. Tuzun Y, Yazici H, Pazarli H et al : The usefulness of the nonspecific skin hyperactivity(the pathergy test) in Behcet's disease in Turkey. Acta Derm Venereol (Stockh) 59 : 77, 1979
  25. Davies PG, Fordham JN, Kirwan JR et al : The pathergy test and Behcet's syndrome in Britain. Ann Rheun Dis 43 : 70, 1984 https://doi.org/10.1136/ard.43.1.70
  26. Yazici H, Yurdakul S, Hamuryudan V : The management of Behcet's syndrome: how are we doing ? Clin Exp Rheumatol 17 : 145, 1999
  27. Bang D : Treatment of Behcet disease. Yonsei Med J 38 : 401, 1997 https://doi.org/10.3349/ymj.1997.38.6.401
  28. Sakane T, Takeno M, Suzuki Net al : Behcet disease. N Engl J Med 341 : 1284, 1999 https://doi.org/10.1056/NEJM199910213411707
  29. Sakane T : New perspective on Behcet disease. Int Rev Immunol 14 : 89, 1997 https://doi.org/10.3109/08830189709116847
  30. Hamuryudan V, Mat C, Saip S, et al : Thalidomide in the treatment of the mucocutaneous lesions of the Behcet syndrome: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 128 : 443, 1998. https://doi.org/10.7326/0003-4819-128-6-199803150-00004
  31. Zouboulis CC, Orfanos CE : Treatment of Adamantiades- Behcet disease with systemic interferon-alpha. Arch Dermatol 134 : 1010, 1998 https://doi.org/10.1001/archderm.134.8.1010
  32. Kaklamani VG, Vaiopoulos G, Kaklamanis PG : Behcet disease. Semin Arthritis Rheum 27 : 197, 1998 https://doi.org/10.1016/S0049-0172(98)80001-2