YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Inhibitory Activity of 8-Aminowogonin Analogues Against Prostaglandin $E_2$ Production

8-아미노우고닌 유도체의 Prostaglandin $E_2$ 생성에 대한 저해작용

  • Jang, Jin-Hee (College of Pharmacy, Kangwon National University) ;
  • Sin, Kwan-Seog (College of Pharmacy, Kangwon National University) ;
  • Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) ;
  • Park, Hae-Il (College of Pharmacy, Kangwon National University)
  • Published : 2008.02.29
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Abstract

8-Acyl and 8-sulfonylamidowogonin analogues were synthesized as potential anti-inflammatory agents. Nitration of 5,7-dihydroxyflavone (chrysin) followed by methylation of phenol groups and reduction of nitro group yielded 8-aminowogonin analogues. Acylation and sufonylation of 8-aminowogonin followed by demethylation reactions gave the title compunds. The synthesized wogonin analogues showed much reduced inhibitory activity on prostaglandin $E_2\;(PGE_2)$ production.

Keywords

References

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