Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Hepatoprotective Effects of Plants Extracts from Baekdu Mountain on Tacrine-induced Cytotoxicity in HepG2 Cells

타크린으로 유발한 간 세포 독성에 대한 백두산 식물 추출물의 보호 효과

  • Lee, Dong-Sung (College of Pharmacy, Wonkwang University) ;
  • Jeong, Gil-Saeng (Institute for Radiological Imaging Science, Wonkwang University) ;
  • An, Ren-Bo (College of Pharmacy, Yanbian University) ;
  • Li, Bin (College of Pharmacy, Wonkwang University) ;
  • Byun, E-Ri-Sa (College of Pharmacy, Wonkwang University) ;
  • Yoon, Kwon-Ha (Institute for Radiological Imaging Science, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
  • 이동성 (원광대학교 약학대학) ;
  • 정길생 (원광대학교 익산방사선연구센터) ;
  • 안인파 (연변대학교 약학대학) ;
  • 리빈 (원광대학교 약학대학) ;
  • 변에리사 (원광대학교 약학대학) ;
  • 윤권하 (원광대학교 익산방사선연구센터) ;
  • 김윤철 (원광대학교 약학대학)
  • Published : 2008.03.31
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Abstract

The present study represents the screening of the protective effects of herbal methanolic extracts from Baekdu mountain against tacrine-induced cytotoxicity in HepG2 cells. Tacrine is an acetylcholinesterase inhibitor, and used for the treatment of Alzheimer's disease. However, administration of tacrine for the treatment of Alzheimer's disease results in a reversible hepatotoxicity in 30-50% of patients, consequently limiting clinical use. Therefore, studies for natural products with protective effect on the tacrine-induced hepatotoxicity would be valuable as providing potential therapeutic use. 109 plant sources were collected in Baekdu mountain, and extracted with methanol. These extracts had been screened the protective effects against tacrine-induced cytotoxicity in HepG2 cells at the 100 and 300 ${\mu}g/ml$. Of these, ten methanolic extracts, roots of Ampelosis japonica, aerial parts of Berberis amurensis, aerial parts of Sedum aizoon, aerial parts of Lespedeza tomentosa, aerial parts of Lespedeza juncea, aerial parts of Hypenricum ascyron, stem barks of Syringa reticulata, fruits of Gleditsia japonica, aerial parts of Chamaenerion angustifolium, branches of Ginkgo biloba, showed significant protective effects against tacrine-induced cytotoxicity in HepG2 cells.

Keywords

References

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