Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
권호 표지
DOI QR코드

DOI QR Code

Antinarcotic Effect of Ginseng

인삼의 마약중독 해독효과

  • Oh, Sei-Kwan (Department of Neuroscience, School of Medicine, Ewha Womans University)
  • 오세관 (이화여자대학교 의과대학 뇌신경과학교실)
  • Published : 2008.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Ginseng saponin has been shown to inhibit the development of dependence on morphine, cocaine, methamphetamine, but the antinarcotics effects of ginseng on nalbuphine remains still largely unknown. Ginseng administration attenuated the naloxone-induced jumping behavior on nalbuphine dependent mice. The development of morphine dependence was mediated through ${\mu}-opioid$ receptor, however, development of nalbuphine dependence was mediated through ${\kappa}-opioid$ receptor. However, it was found that the efficacy of analgesic antagonism of GTS was mediated through the serotonergic mechanism, not mediated through the opioid receptor. In addition, ginseng administration modulated cellular signal transduction in the brain. The increased NMDA receptor subunit (NR1, pNR1), phosphate extracellular signal regulated protein kinase (pERK), phosphate cAMP response element binding protein (pCREB) expression by nalbuphine was decreased by the administration of ginseng powder in cortex, hippocampus, striatum of rat brain. These results suggest that ginseng could be one of the targets of antinarcotic therapies to reduce the development of tolerance and dependence on nalbuphine as well as morphine.

Keywords

References

  1. 조선인삼사 5권 (1937).
  2. Kim, H.S., Jang, C.G. and Lee, M.K. : Antinarcotic effects of the standardized ginseng extract G115 on morphine. Planta Med. 56, 158162 (1990).
  3. CoutinhoNetto, J., AbdulGhani, A. and Bradford, H.F. : Suppression of evoked and spontaneous release of neurotransmitters in vivo by morphine. Biochem. Pharmacol. 29, 2777- 2780 (1980). https://doi.org/10.1016/0006-2952(80)90011-8
  4. Aghajanian, G.K., Kogan, J.H. and Moghaddam, B. : Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Res. 636, 126-130 (1994). https://doi.org/10.1016/0006-8993(94)90186-4
  5. Koyuncuoglu, H., Dizdar, Y., Aricioglu, F. and Sayin, U. : Effects of MK801 on morphine physical dependence: attenuation and intensification. Pharmacol. Biochem. Behav. 43, 487-490 (1992). https://doi.org/10.1016/0091-3057(92)90181-E
  6. Kim, H.S., Oh, K.W., Rheu, H.M. and Kim, S.H. : Antagonism of U50,488Hinduced antinociception by ginseng total saponin is dependent on serotonergic mechanism. Pharmacol. Biochem. Behav. 42, 587-593 (1992). https://doi.org/10.1016/0091-3057(92)90003-X
  7. Kim, H.S., Shin, S.H., Choi, K.J. and Kim, S.C. : Effect of Panax ginseng on the development of morphine tolerance and dependence. Kor. J. Ginseng Sci. 11, 123-129 (1987).
  8. Kim, H.S., Oh, K.W., Park, W.K., Yamano, S. and Toki, S. Effect of Panax ginseng on the development of morphine tolerance and dependence. Kor. J. Ginseng Sci. 11, 182-190 (1987).
  9. Nabata, H., Saito, H. and Takagi, K. : Pharmacological studies of neutral saponin (GNS) of Panax ginseng root. Jpn. J. Pharmacol. 23, 29-41 (1973). https://doi.org/10.1254/jjp.23.29
  10. Bhargava, H.N. and Ramarao, P. : The effect of panax ginseng on the development of tolerance to the pharmacological actions of morphine in rats. Gen. Pharmacol. 22, 521- 525 (1991). https://doi.org/10.1016/0306-3623(91)90017-Z
  11. Watanabe J., Oh, K.W., Kim, H.S., Takahashi M. and Kaneto H. : A nonopioid mechanism in the inhibitory effect of ginseng saponins on electrically evoked contractions of guineapig ileum and mouse vas deferens. J. PharmacobioDyn. 11, 453-458 (1988). https://doi.org/10.1248/bpb1978.11.453
  12. Kim, H.S., Lee, G.S. and Oh, K.W. : Inhibitory effect of ginseng total saponins on the development of tolerance to U50,488Hinduced antinociception is dependent on serotonergic mechanisms. Kor. J. Ginseng Sci. 19, 202-205 (1995).
  13. Kim, H.S., Oh, K.W., Park, W.K., Choi, J.W. and Bae, D.S. : Effects of panax ginseng on the development of morphine induced tolerance and dependence (IV). Arch. Pharm. Res. 10, 188-192 (1987). https://doi.org/10.1007/BF02861912
  14. Kim, H.S., Kim, S.H., Lee, M.K., Choi, K.J. and Kim, S.C. : Effects of ginseng leaf saponin on the development of morphine tolerance and dependence in mice. Kor. J. Ginseng Sci. 13, 813 (1989).
  15. Kim, D.H., Yoo, H.S., Jang, C.G., Kang, J.S., Kim, S.S., Choi, K.H., Jang, S.Y. and Oh, S. : Inhibitory action of the ginseng total saponin on the nalbuphineinduced tolerance and withdrawal syndrome. J. Ginseng Res. 29, 86-93 (2005). https://doi.org/10.5142/JGR.2005.29.2.086
  16. 오세관 : 고려홍삼의 연산 날부핀 부작용 개선에 관한 연구. 고려인삼학회 용역보고서 (2004)
  17. Kim, H.S., Kang, J.G., Seong, Y.H., Nam, K.Y. and Oh, K.W. : Blockade by ginseng total saponin of the development of cocaine induced reverse tolerance and dopamine receptor supersensitivity in mice. Pharmacol. Biochem. Behav. 50, 23-27 (1995). https://doi.org/10.1016/0091-3057(94)00224-7
  18. Kim, H.S., Kang, J.G., Rheu, H.M., Cho, D.H. and Oh, K.W. : Blockade by ginseng total saponin of the development of methamphetamine reverse tolerance and dopamine receptor supersensitivity in mice. Planta Med. 61, 2225 (1995).
  19. Tokuyama, S., Oh, K.W., Kim, H.S., Takahashi, M. and Kaneto, H. : Blockade by ginseng extract of the development of reverse tolerance to the ambulationaccelerating effect of methamphetamine in mice. Jpn. J. Pharmacol. 59, 423425 (1992).