Food Science and Preservation (한국식품저장유통학회지)

The Korean Society of Food Preservation (한국식품저장유통학회)
권호 표지

Determination of Heavy Metal Contents in Medicinal Herb

유통 한약재의 중금속 함량 조사

  • Lee, Mi-Kyung (Department of Food and Nutrition, Kwang-ju Health College) ;
  • Park, Jung-Suk (Department of Complementary Alternative Therapy, Kwang-ju Womens University) ;
  • Lim, Hyun-Cheol (Food & Drug Analysis Division, Jeollanamdo Institute of Health and Environment) ;
  • Na, Hwan-Sik (Food & Drug Analysis Division, Jeollanamdo Institute of Health and Environment)
  • 이미경 (광주보건대학 식품영양과) ;
  • 박정숙 (광주여자대학교 대체요법학과) ;
  • 임현철 (전라남도보건환경연구원 식품약품분석과) ;
  • 나환식 (전라남도보건환경연구원 식품약품분석과)
  • Published : 2008.04.28
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Abstract

Comparative study was performed on heavy metal contents among domestic herbal medicines and imported one. The heavy metal contents in 89 samples of 65 types of herbal medicines were measured by inductively coupled plasma atomic emission spectrometry (ICP-AES) and mercury analyzer. The mean values of heavy metal contents (mg/kg) for herbal medicines were as follows: Hg, 0.010 (domestic: 0.010, imported: 0.010); Pb, 0.380 (domestic: 0.311, imported: 0.449); Cd, 0.080 (domestic: 0.101, imported: 0.059); As, 2.085 (domestic: 1.845, imported: 2.324); Mn, 31.564 (domestic: 33.844, imported: 29.283); Zn, 15.436 (domestic: 18.703, imported: 12.168); Cu, 3.406 (domestic: 3.374, imported: 3.437); Fe, 134.944 (domestic: 108.327, imported: 161.561). The measured values of Hg, Pb and Cd of domestic and imported herbal medicines showed lower levels than the recommended levels of those in herbal medicines by WHO/PHARM (Pb : not more than 5 mg/kg, Cd : not more than 0.3 mg/kg). This results will he used as a basic data for the future legislation on the regulation and control of heavy metal contents of herbal medicines.

국내에서 유통되고 있는 한약재의 안전성을 검토하고자 국내산 한약재 28종, 33건과 수입산 37종 56건 등 총 65종 89건을 구입하여 중금속 함량을 조사하였다. Hg의 경우 평균 함유량이 0.010 mg/kg (domestic : 0.010, imported : 0.010)이었으며, Pb의 경우에는 0.380 mg/kg (domestic : 0.311, imported 0.449), Cd은 0.080 mg/kg (domestic : 0.101, imported : 0.059), As를 분석한 결과 2.085 mg/kg (domestic : 1.845, imported : 2.324)으로 나타났다. 또한 Mn은 31.564 mg/kg (domestic 33.844, imported : 29.283), Zn은 15.436 mg/kg (domestic : 18.703, imported : 12.168), Cu가 3.406 mg/kg (domestic : 3.374, imported : 3.437), Fe의 경우 134.944 mg/kg (domestic : 108.327, imported : 161.561)으로 분석되었다. Hg, Pb, Cd,와 As에 대한 전반적인 경향은 대부분의 검사항목에서 안전한 것으로 분석되었으며, 수입산 한약재와 국내산 한약재간의 특별한 차이를 보이지 않았다. 그러나 극히 일부 시료에서 비록 적은 양이지만 기준치를 약간 초과하는 결과를 보여 향후 안전한 한약재를 국민들에게 공급하기 위해서는 보다 더 세심한 관리가 필요할 것으로 생각된다. 이러한 결과로 보아 추후 개별 중금속기준치 설정 및 국내 유통 생약의 개별 중금속 함유량실태 파악하는데 있어서 기초 자료로 활용이 가능할 것으로 판단된다.

Keywords

References

  1. Han, K., Kwon, D.Y., Lee, S.G., Park, S.K., Kim, C.S. and Kim, Y.K. (2006) The present state of Korean herbal preparation production and possible improvement plan. Korean J. Oriental Med. Prescript., 14, 30-41
  2. Lee, S.Y., Kim, M.J. and Lim, D.S. (1988) Comparison of the components and the contents in the roots of Veroniastrum. Kor. J. Pharmacogn., 19, 34-38
  3. Yook, H.S., Cha, B.S., Jo, S.K. and Byun, M.W. (1998) Effects of gamma irradiation on microbial detection, extraction yields and physiological effectiveness of Korean medicinal plants. Korean J. Food Sci. Technol., 30, 581-589
  4. Massaro, E.J. (1990) Handbook of human toxicology. Boca Raton Press, New York, p. 149-188
  5. Rhee, J.S. (1995) A study on the content of heavy metal in domestic or foreign oriental medicine by means of quantitative analytical method, M. S. Thesis, Dept. of Oriental Medicine, Kyung Hee University, Seoul, Korea
  6. WHO. (1997) "Lead (Environmental Health Criteria 3)". WHO, p. 44-54
  7. Conor Reilly. (1980) "Metal contamination of food." Applied Science Publisher LTD., London, p. 119-122
  8. Conor Reilly. (1991) "Metal contamination of food." 2nd edition, Elsevier science publishers LTD., London, p. 95-98
  9. Choi, J.H., Kim, D.W., Moon, Y.S. and Chung, D.S. (1996) Feeding effect of oriental medicine on the functional properties of pig meat. J. Korean Soc. Food Nutr., 25, 110-117
  10. Hwang, J.B., Yang, M.O. and Shin, H.K. (1998) Survey for amine acid of medicinal herbs. Korean J. Food Sci. Technol., 30, 35-41
  11. Kim, C.M., Song, B.J. and Na, H.S. (2000) Determination of sulfite contents in medicinal herbs. J. Korean Soc. Food Sci. Nutr., 29, 375-379
  12. Lee, M.J., Lee, Y.J., Han, S.B., Moon, C.S., Lee, Y.D., Jung, H.Y., Park, H.R., Yoo, S.Y., Lee, S.O., Choi, Y.H., Kim, H.S., Lee, K.J., Bang, S.Y., Mun, S.S. and Kim, M.C. (1998) A study on the heavy metal contents of medicinal plants in Korea. Ann. Report KFDA, 2, 253-264
  13. Joo, S.M., Kim, S.K. and Rho, Y.S. (1984) Studies on the quantitative analysis and elution of metals in crude drugs (I). Bull. Kyung Hee Pharm. Sci., 12, 25-32
  14. Joo, S.M. and Rho, Y.S. (1984) Studies on the quantitative analysis of metals in crude drugs (II). Bull. Kyung Hee Pharm. Sci., 13, 149-157
  15. KFDA. (2005) Food Code. Munyoung-sa, Seoul, p. 35-36
  16. KFDA. (2005) Food Code (a separate volume). Munyoung-sa, Seoul, p. 62-72
  17. Rigaku Industrial Corporation. (1979) Rigaku Mercury Analyzer SP Technical Report
  18. Kim, J.S., Hwang, S.W., Kim, J.M. and Ma, J.Y. (2001) Monitoring research for heavy metals as endocrine disruptors in Sibjeondaebotang and its ingredients herbal medicines(II). Yakhak Hoeji, 45, 448-454
  19. Cha, Y.Y., Heo, S.K., Kim, D.G., Baik, T.H., Seo, H.S., Park, H.S., Cha, B.C. and Seo, S.H. (2007) Determination of heavy metals and residual pesticides in oriental medical materials. Kor. J. Oriental Physiol. Pathol., 21, 226-230