Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Genotoxicological Safety of Octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate from Gallic and Linoleic Acids and Its Biological Functions in Cream-based Emulsion

Gallic Acid와 Linoleic Acid로부터 합성한 Octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate의 유전독성학적 안전성 및 화장품 제형을 통한 생리 기능성 평가

  • Jung, Sa-Moo-El (Dept. of Animal Science & Biotechnology, Chungnam National University) ;
  • Song, Hyun-Pa (Dept. of Animal Science & Biotechnology, Chungnam National University) ;
  • Lee, Na-Young (Dept. of Food Science and Biotechnology, Chonbuk National University) ;
  • Jang, Ae-Ra (Quality Control and Utilization Division, National Institute of Animal Science, RDA) ;
  • Jo, Cheo-Run (Dept. of Animal Science & Biotechnology, Chungnam National University)
  • 정사무엘 (충남대학교 동물자원생명과학) ;
  • 송현파 (충남대학교 동물자원생명과학) ;
  • 이나영 (전북대학교 식품공학과) ;
  • 장애라 (농촌진흥청 축산과학원 축산물이용과) ;
  • 조철훈 (충남대학교 동물자원생명과학)
  • Published : 2008.06.30
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Abstract

The objective of this study was to investigate the genotoxicological safety and biological functions of octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate (GA-LA) in cream-based emulsion for future application as a functional cosmetic material as well as food. GA-LA was synthesized chemically from gallic acid and linoleic acid. The Ames test showed that GA-LA did not have mutagenical toxicity. The control cream-based emulsion containing GA-LA was prepared by commercial method and tested for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Ferric reducing antioxidant power (FRAP) and inhibition effect against tyrosinase of the emulsions were tested for the evaluation of antioxidative and skin-whitening activities. The results showed that DPPH radical scavenging activity in the cream-based emulsion containing GA-LA was higher (52.65%) than that of the control (4.30%). The FRAP value of the sample was 12.85%, however, no activity was found in control. The inhibition effect of tyrosinase showed also a higher value (26.29%) when compared to the control. The results indicate that GA-LA, which showed superior antioxidative and skin-whitening activities in cream-based emulsion, is a useful functional material applicable in cosmetic products as well as food.

Gallic acid와 linoleic acid의 합성물인 octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate(GA-LA)의 화장품산업에서의 이용 가능성을 알아보기 위하여 유전독성학적 안전성을 확인하고 크림 베이스 유화물을 사용하여 전자공여능, FRAP 및 tyrosinase 활성 억제능력과 같은 GA-LA의 생리 기능성 실험을 실시하였다. 그 결과 유전독성학적 안전성이 확인되었고, 산화에 의한 피부의 노화를 억제하기 위한 항산화 능력과 미백과 관련된 tyrosinase 활성 억제 능력이 있음이 확인되었다. 따라서 GA-LA는 식품산업뿐만 아니라 화장품산업에서 유용한 기능성 물질로 쓰일 수 있을 것이라고 생각되어진다.

Keywords

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