대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제29권2호
  • /
  • Pages.151-158
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  • 2008
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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변화하는 혈압의 영향을 받지 않는 동맥 벽의 강화도 측정 방법 제안 : 대동맥 확장지수

A suggestion of Aortic wall Stiffness Evaluation Technique Independent on Changeable Blood Pressure : Aortic Distensibility Index

  • 서지혜 (경북대학교 병원 영상의학과) ;
  • 최동호 (경북대학교 병원 영상의학과) ;
  • 오수경 (경북대학교 병원 영상의학과) ;
  • ;
  • 이종민 (경북대학교 병원 영상의학과)
  • Seo, Jee-Hye (Department of Diagnostic Radiology, Kyungpook National University Hospital) ;
  • Choi, Dong-Ho (Department of Diagnostic Radiology, Kyungpook National University Hospital) ;
  • Wu, Zhuqing (Department of Diagnostic Radiology, Kyungpook National University Hospital) ;
  • Rienmueller, Rainer (Univ.-Klinik f. Radiologie, LKH-Universitaetskliniken GRAZ) ;
  • Lee, Jong-Min (Department of Diagnostic Radiology, Kyungpook National University Hospital)
  • 발행 : 2008.04.30
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초록

To evaluate aortic wall stiffness without influence of different background blood pressure, a new technique was developed and verified. At eight swine descending aortae, volume-pressure measurement was performed using custom-made system. Based on averaged pressure-volume curve, aortic distensibility index was formulated to evaluate aortic wall stiffness regardless of variable blood pressure and aortic size. The variability of aortic distensibility index by pressure change was compared with other parameters for wall stiffness evaluation. Subsequently, the aortic distensibility index was calculated at 100 contrast-enhanced EBCT data sets of normal volunteers in regular health screening program. The measured aortic distensibility index was compared with age, coronary calcium score, and aortic calcium score. Between 50 and 360 mmHg of blood pressure, the coefficient of variance of aortic distensibility index was 22.00% as comparing with 88.99% of classical compliance. Based on age, aortic distensibility index showed correlation coefficient of 0.55, whereas classical compliance showed 0.26. The correlation coefficient with modified aortic calcification was 0.43. Linear regression study revealed statistical significance of correlation coefficients. The aortic distensibility index, the method to evaluate aortic wall stiffness free from variable blood pressure and aortic size, was developed and verified with significant practical feasibility.

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참고문헌

  1. Wilmer W Nichols and Michael F. O'Rourke, McDonald's Blood Flow In Arteries 3rd editions, London, England: 1990, pp. 77- 114
  2. Wada T, kodaira K, Fujishiro K, Maie K, Tsukiyama E, Fukumoto T, Uchida T and Yamazaki S, 'Correlation of ultrasoundmeasured common carotid artery stiffness with pathological findings,' Arterioscler Thrombo., vol. 14, no. 3, pp.479-482, 1994 https://doi.org/10.1161/01.ATV.14.3.479
  3. Frank O., 'Die Theorie der Pulswellen,' Z Biol, vol. 85, pp. 91- 130, 1926
  4. Goldwyn RM and Watt TB Jr, 'Arterial pressure pulse contour analysis via a mathematical model for the clinical quantification of human vascular properties,' IEEE Trans Biomed Eng., vol. 14, pp. 11-17, 1967 https://doi.org/10.1109/TBME.1967.4502455
  5. Randall OS, Esler MD, Calfee RV, Bulloch GF, Maisel AS, and Culp B, 'Arterial compliance in hypertension,' Aust NZ JMed 6, Suppl, vol. 2, pp. 49-59, 1976
  6. Benetos A, Adamopoulos C, Bureau F, et al, 'Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6 year period,' Circulation, vol. 105. pp. 1202-1207, 2002 https://doi.org/10.1161/hc1002.105135
  7. Gow BS and Taylor MG, 'Measurement of viscoelastic properties of arteries in the living dob,' Circ Res., vol. 23, pp. 111-122, 1968 https://doi.org/10.1161/01.RES.23.1.111
  8. Luchsinger PC, Sachs M, and Patel DJ, 'Pressure-radius relationship in large blood vessels of man,' Circ Res., vol. 11, pp. 885- 888, 1962 https://doi.org/10.1161/01.RES.11.5.885
  9. Patel DJ, de Freitas FM, Greenfield JC, and Fry DL, 'Relationship of radius to pressure along the aorta in living dogs,' J Appl Physiol., vol. 18, pp. 1111-1117, 1963 https://doi.org/10.1152/jappl.1963.18.6.1111
  10. O'Rourke MF, Staessen JA, Viachopoulos C, Dupner D and Plante GE, 'Clinical applications of arterial stiffness: definitions and reference values,' Am J Hypertens Circ Res., vol. 18, pp. 426-44, 2002
  11. Cockcroft VR and Wilkinson IB, 'Arterial stiffness and pulse contour analysis: an age-old concept revisited,' Circ Res., vol. 103, pp. 379-80, 2002
  12. Kaibe M, Ohishi M, Komai N, Ito N, Katsuya T, Rakugi H, et al, 'Arterial stiffness index; a new evaluation for arterial stiffness in elderly patients with essential hypertension,' Geriatrics Gerontol Intern Circ Res., vol. 2, pp. 199-203, 2002 https://doi.org/10.1046/j.1444-1586.2002.00045.x
  13. Helmut F. Kuecherer, Armin J and Hartmut K, 'Evaluation of aortic compliance in humans,' Circ Physiol., vol. 278, pp. 1411- 1413, 2000 https://doi.org/10.1152/ajpheart.2000.278.5.H1411
  14. Bergel DH, 'The static elastic properies of the arterial wall,' J Physiol., vol. 15, pp. 445-457, 1961
  15. Valerie Marque, Helma Van Essen, Harry A.J. Struijker B, et al, 'Determination of Aortic Elastic Modulus by pulse wave velocity and wall tracking in a rat model of aortic stiffness,' J Vasc Res., vol. 38, pp. 546-550, 2001 https://doi.org/10.1159/000051090
  16. Hoeks APG, Ruissen CJ, Hick P and Reneman RS, 'Transcutaneous detection of relative changes in artery diameter,' Ultrasound Med Biol., vol. 11, pp. 51-59, 1985 https://doi.org/10.1016/0301-5629(85)90007-9