Macromolecular Research

  • 제16권5호
  • /
  • Pages.418-423
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  • 2008
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  • 1598-5032(pISSN)
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  • 2092-7673(eISSN)
한국고분자학회 (The Polymer Society of Korea)
권호 표지

Characterizations and Release Behavior of Poly [(R)-3-hydroxy butyrate]-co-Methoxy Poly(ethylene glycol) with Various Block Ratios

  • Jeong, Kwan-Ho (Department of Applied Chemistry and Biological Engineering, Chungnam National University) ;
  • Kwon, Seung-Ho (Department of Applied Chemistry and Biological Engineering, Chungnam National University) ;
  • Kim, Young-Jin (Department of Applied Chemistry and Biological Engineering, Chungnam National University)
  • 발행 : 2008.07.31
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초록

Poly[(R)-3-hydroxy butyrate] (PHB) and methoxy poly(ethylene glycol) (mPEG) were conjugated by the transesterification reaction with tin(II)-ethylhexanoate (Sn(Oct)-II) as a catalyst. Hydrophobic PHB and hydrophilic mPEG formed an amphiphilic block copolymer which was formed with the self-assembled polymeric micelle in aqueous solution. In this study, we tried to determine the optimum ratio of hydrophobic/hydrophilic segments for controlled drug delivery. The particle size and shape of the polymeric micelle were measured by atomic force microscopy (AFM) and transmission electron microscopy (TEM). Their size were 61-102 nm with various block ratios. Griseofulvin was loaded in the polymeric micelle as a hydrophobic model drug. The loading efficiency and release profile were measured by high performance liquid chromatography (HPLC). The model drug in our system was constantly released for 48 h.

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